Device for real time analysis of particles suspended in a fluid and method for the analysis of said particles
一种颗粒、流体的技术，应用在定位单元的装置,分析浸在流体中的颗粒领域，能够解决位置控制系统复杂、昂贵、滞留区不稳定等问题，达到避免损坏的效果
Active Publication Date: 2017-08-29
CELLDYNAMICS I SRL
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[0004] These solutions have the disadvantage that the systems used require rather complex means for trapping the particles to be analyzed such as lasers, quadrupole configurations or electromagnetic systems
[0010] These devices cannot be used to directly control the flow of a fluid acting on a particle to be analyzed, where the particle is not moved (driven) directly by the action of the flow applied to it, but moves through a region of minimum flow (retention region) while indirect movement: a change in the flow rate of one of the induced continuous streams in the analysis chamber will create instability in the stagnation zone, which does not necessarily result in maintaining the movement of the particles within the trap
This solution of providing particle capture by continuous fluid flow involves on the one hand the use of large volumes of fluid (often expensive in the case of biological analysis) and on the other hand makes the position control system quite complex and expensive
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[0034] The following paragraphs describe various exemplary embodiments of the invention. By way of example and for ease of understanding, the embodiments will be explained below with reference to the analysis of biological material, such as cells or cell clusters, expressed in general terms of particles. In any event, it is to be understood that the devices and methods of the present invention may also be used to control the location of particles of a biological nature in a fluid by selectively generating localized flow. In particular, the solutions described with reference to the illustrative examples described below can also be used to analyze particles other than cells or cell clusters.
[0035] As a result, the term "particle" used in the context of the present invention to denote cells, cell masses or biological material in general can also be used to denote different objects such as micro- and nanoparticles, residual particles from industrial production processes, partic...
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The present invention refers to a device for the analysis of a particle comprising an analysis chamber adapted to contain a positioning fluid. A parameter of the particle suspended in the positioning fluid is detected by means of a detection and control unit. A positioning unit, during a particle analysis operation, is activated and deactivated on the basis of the detected parameter of the particle. The detection and control unit can activate the at least one positioning unit so as to generate a temporary positioning flow in the positioning fluid, such that said temporary positioning flow acts directly on the particle and drives the position of the particle so as to move it into a predefined position in the analysis chamber. The detection and control unit can also deactivate the at least one positioning unit when the particle to be analyzed is in the predefined position, such that the positioning fluid is at rest.
Description
technical field [0001] The present invention relates to a device for analyzing particles immersed in a fluid. In particular, the invention relates to a device comprising a positioning unit for controlling the position of a particle to be analyzed in an analysis chamber. The control over the position of the particles to be analyzed occurs by driving the particles to be analyzed with a flow selectively generated in the fluid within the analysis chamber. The invention also relates to a method for analyzing particles immersed in a fluid. Background technique [0002] Devices and methods are known from the prior art for carrying out the analysis of biological materials, in particular single cells, by using microfluidic systems. In particular, microfluidic systems for cellular analysis or analysis of biological material enable introduction of the material to be analyzed into an analysis chamber and capture of the material to be analyzed in the analysis chamber. For analysis pur...
Claims
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IPC IPC(8): G01N15/10
CPCG01N15/10G01N2015/1006G01N2015/1027B01L3/502761B01L2200/0663B01L2400/0445B01L2400/0481B01L2400/0487G01N2015/1415
Inventor D·加佐拉S·帕斯夸E·琴图廖尼
Owner CELLDYNAMICS I SRL