Nano lipid carrier sun protection gel and preparation method thereof

Abstract

The invention discloses nano lipid carrier (NLC) sun protection gel and a preparation method thereof. The NLC-gel takes sodium carboxymethyl cellulose as a substrate; liquid grease and solid grease form a lipid carrier; an RES and an organic sun protector are wrapped into the lipid carrier together; via emulsification and ultrasonic treatment, the NLC-gel is prepared. The liquid grease is glyceryl caprylate-caprate; the solid grease is shea nut grease; the organic sun protector is prepared from 4-methylbenzylidene camphor (Parsol50000), butyl methoxy dibenzoyl methane (Parsol1789) and ethylhexyl methoxycinnamate (ParsolMCX). The experimental design of the nano lipid carrier sun protection gel is realized by using JMP7 software; an experimental result is analyzed through spss, so that data are precise and the result is reliable; due to a solid framework structure of the nano lipid carrier, the light instability of the RES and the organic sun protector is reduced; the RES has ultraviolet ray resisting and cell protecting functions; a new strategy is provided for solving the problems of photosensitized reaction and phototoxicity which are easy to generate by a sun protection product.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetic preparation technology. It involves the preparation method of a nano-scale carrier loaded with resveratrol and organic sunscreen and its formulation optimization research. Background technique [0002] The plateau area in western my country has long sunshine hours and high ultraviolet radiation intensity, which makes human skin vulnerable to damage. In addition, the plateau air is dry and windy and sandy, and the skin is prone to dehydration and peeling, which further aggravates the damage of ultraviolet rays to the skin. So solar dermatitis has become a common disease. According to the intensity of ultraviolet radiation, the length of time and the reaction of lesions, sunburn can be divided into two categories: "immediate sunburn" and "cumulative sunburn". Immediateness is caused by intense sun exposure to the skin in a short period of time. Cumulative sunburn does not have...

AI Technical Summary

Problems solved by technology

In the survey of commercially available plateau sunscreen products, it was found that: (1) Most of the products adopt W / O emulsification system and carry physical and chemical sunscreens at the same time, so the products are greasy and not refreshing. produce discomfort

At the same time, this type of product has poor moisturizing properties

(2) The stability of the active ingredient is severely reduced due to strong light exposure

(4) Commercially available sunscreen gels are mostly water-soluble chemical sunscreen agents. Although they have moisturizing effect, the available sunscreen agents are limited, and the sunscreen effect is not obvious, and the surfactant content in the prescription is high, which is more irritating to the skin. Big

Hydrogel has a fluid viscous behavior, which allows it to be in good contact with the skin, and has a refreshing texture, which has good water-locking and moisturizing effects, but it can only be loaded with water-soluble sunscreen agents, and the sunscreen effect is poor

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