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Cyathin compounds, preparation method and application of cyathin compounds to neuroinflammation resisting

A technology for ovonidin and neuroinflammation, applied in the field of medicine, can solve the problems of limited curative effect, inability to restore the cognitive function of patients, and inability to prevent the pathogenesis of AD

Active Publication Date: 2017-09-01
NORTHWEST A & F UNIV
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  • Claims
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Problems solved by technology

The current drugs can only improve the symptoms of AD patients, neither prevent the progression of AD nor restore the lost cognitive function of patients, so the curative effect is limited
So far, no revolutionary drug has emerged

Method used

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  • Cyathin compounds, preparation method and application of cyathin compounds to neuroinflammation resisting

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Embodiment Construction

[0090] The ten compounds of the present invention, nestomycin 1-10, are isolated from the fermented liquid of Cyathus africanus. The Nestella africanum was purchased from the China General Microorganism Culture Collection and Management Center, number: CGMCC 5.1163; the strain was preserved in the Natural Medicinal Chemistry Research Center, School of Chemistry and Pharmacy, Northwest A&F University, number: (No.CA20150728).

[0091] The storage and activation culture conditions of the N. africanus are as follows: the preserved strain adopts a PDA slant medium. To activate the strain, inoculate the strain on a PDA plate, activate and cultivate it at 28°C for 7 days, until the plate is covered with mycelium. PDA plate medium: Each liter medium contains 200g potatoes, 20g glucose, and 16g agar powder.

[0092] One, the extraction method of the compound of the present invention, identification and anti-neurinflammation assay and application:

[0093] 1. Experimental materials ...

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Abstract

The invention discloses cyathin compounds, a preparation method and application of the cyathin compounds to neuroinflammation resisting, particularly relates to 10 cyathin compounds, and a preparation method and application of the cyathin compounds to preparation of cyclooxygenase-2 (COX-2) activity inhibiting and nitric oxide synthase (iNOS) activity inhibiting, and discloses chemical structural formulas of the compounds and corresponding nuclear magnetic data. The compounds are separated from fermentation liquor of a strain of Africa cyathus stercoreus, which is bought from China General Microbiological Culture Collection Center, and the serial number is CGMCC 5.1163.

Description

technical field [0001] The present invention belongs to the field of medicine, and relates to an antocin compound, a preparation method and its anti-neurinflammation application, in particular to 10 anetocin compounds, a preparation method and the preparation method for inhibiting cyclooxygenase-2 activity and Use of Nitric Oxide Synthase Active Drugs. Background technique [0002] With the acceleration of population aging, Alzheimer's disease (AD) has become a common neurodegenerative disease. According to the "Global Alzheimer's Disease AD Report", about 46.8 million people worldwide suffered from dementia in 2015 , and is growing at a rate of doubling every 20 years. It is estimated that by 2050, the number of dementia patients worldwide will reach 131.5 million. The current drugs can only improve the symptoms of AD patients, neither prevent the progression of AD nor restore the lost cognitive function of patients, so the curative effect is limited. So far, no revolutio...

Claims

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Application Information

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IPC IPC(8): C07D493/08C07D493/18C07C49/737C12P17/18C12P15/00A61P29/00A61P25/00C12R1/645
CPCC07C49/737C07D493/08C07D493/18C12P15/00C12P17/18
Inventor 高锦明魏景寇融巍郭万慧
Owner NORTHWEST A & F UNIV
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