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Nidusin compounds, preparation method and application of anti-neuroinflammation

A technology of ovonidin and compound, applied in the field of medicine, can solve the problems of unable to prevent the pathogenesis of AD, unable to restore the cognitive function of patients, limited curative effect, etc.

Active Publication Date: 2019-04-30
NORTHWEST A & F UNIV
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  • Description
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  • Application Information

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Problems solved by technology

The current drugs can only improve the symptoms of AD patients, neither prevent the progression of AD nor restore the lost cognitive function of patients, so the curative effect is limited
So far, no revolutionary drug has emerged

Method used

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  • Nidusin compounds, preparation method and application of anti-neuroinflammation

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Embodiment Construction

[0090] The ten compounds of the present invention ovocin 1-10 are obtained from the fermentation broth of a strain of Cyathus africanus. The African black egg nest fungus was purchased from the China General Microbial Culture Collection and Management Center, and the number is: CGMCC 5.1163; the bacteria is preserved in the Natural Medicine Chemistry Research Center, School of Chemistry and Pharmacy, Northwest A&F University, and the number is: (No.CA20150728).

[0091] The preservation and activation culture conditions of the African black egg nest fungus are: PDA slant medium is used for preservation of the strain. To activate the strain, inoculate the strain in a PDA plate, activate and cultivate at 28°C for 7 days, until the plate is full of mycelium. PDA plate medium: each liter of medium contains 200g potatoes, 20g glucose and 16g agar powder.

[0092] 1. The extraction method, identification and anti-neuritis determination and application of the compound of the present inve...

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Abstract

The invention discloses cyathin compounds, a preparation method and application of the cyathin compounds to neuroinflammation resisting, particularly relates to 10 cyathin compounds, and a preparation method and application of the cyathin compounds to preparation of cyclooxygenase-2 (COX-2) activity inhibiting and nitric oxide synthase (iNOS) activity inhibiting, and discloses chemical structural formulas of the compounds and corresponding nuclear magnetic data. The compounds are separated from fermentation liquor of a strain of Africa cyathus stercoreus, which is bought from China General Microbiological Culture Collection Center, and the serial number is CGMCC 5.1163.

Description

Technical field [0001] The present invention belongs to the field of medicine, and relates to ovocin compounds, preparation methods and their anti-neuritis applications, in particular 10 ovocin compounds, preparation methods and their use for preparing cyclooxygenase-2 inhibitors Application of nitric oxide synthase active drugs. Background technique [0002] With the increasing acceleration of population aging, Alzheimer disease (Alzheimer disease AD) has become a common neurodegenerative disease. The "Global Alzheimer Disease AD Report" shows that in 2015, approximately 46.8 million people worldwide suffered from dementia. , And is growing at a rate of doubling every 20 years. It is estimated that by 2050, the number of dementia patients worldwide will reach 131.5 million. The current drugs can only improve the symptoms of AD patients, neither prevent the progression of AD nor restore the cognitive functions that the patients have lost, so the efficacy is limited. So far, no ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/08C07D493/18C07C49/737C12P17/18C12P15/00A61P29/00A61P25/00C12R1/645
CPCC07C49/737C07D493/08C07D493/18C12P15/00C12P17/18
Inventor 高锦明魏景寇融巍郭万慧
Owner NORTHWEST A & F UNIV
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