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Ultra-trace liquid sample feeding device

A technology of trace liquid and sample injector, which is applied in the field of biochemical experiments, can solve problems such as unsatisfactory, and achieve the effect of improving the utilization rate

Active Publication Date: 2017-09-26
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, in recent years, a very micro-volume sampler (pipettor) has appeared, and its pipetting method is to use acoustic wave pipetting technology to make the pipette enter the nanoliter pipetting level, but the minimum pipetting volume can only reach 2.5 nanoliters. Lift
[0004] If it is necessary to distribute and pipette more micro-volume liquids, the existing conventional micro-samplers cannot meet the requirements.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0022] Step 1, preparing a capillary, the inner diameter of the capillary is 1 micron, and the outer diameter is 3 microns; the capillary is a glass tube; the side wall of the capillary is opened with a liquid inlet at two-thirds of the height;

[0023] Step 2. Place the copper wire in the capillary, and the copper wire is located at about two-thirds of the middle and back end (the upper part in the figure) of the capillary;

[0024] Step 3. Pump the trace liquid from the left inlet of the capillary into the capillary by the trace liquid pump;

[0025] Step 4. Adjust the temperature of the heating source, and transfer the heat to the copper wire through the heat conduction wire;

[0026] Step 5. Add the liquid drop by drop to the required container through the thermal expansion of the copper wire, and the size of each drop is about 0.1 picoliter.

Embodiment 2

[0028] Step 1, preparing an array sampler composed of a plurality of capillaries, the inner diameter of the capillary is controlled within 1-10 microns, and the outer diameter is controlled within 2-20 microns; each capillary is made of a glass tube; One liquid inlet is opened at the two heights;

[0029] Step 2. Place a copper wire in each capillary, and the copper wire is located at about two-thirds of the middle and back end (the upper part in the figure) of the capillary;

[0030] Step 3. Pump the trace liquid into the capillary from the left inlet of the capillary by the trace liquid pump,

[0031] Step 4. Adjust the temperature of the heating array, and transfer the heat to the copper wire through the heat conduction wire;

[0032] Step 5. Control the XYZ three-axis movement of the sample stage through the computer, and move the sample stage to the desired position;

[0033] Step 6. Add the liquid drop by drop to the required container through the thermal expansion of ...

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Abstract

The invention belongs to the technical field of biochemical experiments and in particular relates to an ultra-trace liquid sample feeding device. The ultra-trace liquid sample feeding device provided by the invention comprises a capillary tube, a mini-type heat conducting device, a heating source and a trace liquid pump, wherein the inner diameter of the capillary tube is 1 to 10 microns and the outer diameter of the capillary tube is 2 to 20 microns; a liquid inlet is formed in a side wall of the capillary tube; the mini-type heat conducting device is arranged in the capillary tube; the heating source is connected with the mini-type heat conducting device and is used for heating the mini-type heat conducting device; the trace liquid pump is used for pumping ultra-trace liquid into the capillary tube from the liquid inlet. The plurality of capillary tubes can be arranged to form an array sample feeding device. According to the ultra-trace liquid sample feeding device provided by the invention, liquid distribution of the ultra-trace liquid is carried out by utilizing a heat expansion principle of the mini-type heat conducting device, so that picoliter-grade liquid sample distribution is realized. By adopting the ultra-trace liquid sample feeding device, the sample feeding difficulty of the ultra-trace liquid of an existing trace sample feeding device is overcome; picoliter-grade sample feeding can be realized and the utilization rate of a trace valuable sample is improved.

Description

technical field [0001] The invention belongs to the technical field of biochemical experiments, and in particular relates to an ultra-micro-volume liquid sampler. Background technique [0002] At present, the suction range of traditional micro-samplers (pipettes) is generally between 0.1-1000 microliters, which is especially suitable for biological experiments or chemical laboratories. Micro-samplers have been developed to this day, and there are various varieties, such as micro-dispensers, multi-channel micro-samplers, etc. The physical principles of sampling are mainly the following two: ① Use air cushion (also known as piston stroke) Add sample; ②Use the piston without air cushion to add sample. [0003] In addition, in recent years, a very micro-volume sampler (pipettor) has appeared, and its pipetting method is to use acoustic wave pipetting technology to make the pipette enter the nanoliter pipetting level, but the minimum pipetting volume can only reach 2.5 nanoliter...

Claims

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Application Information

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IPC IPC(8): B01L3/02
CPCB01L3/02B01L2400/0481
Inventor 潘晓霞郑健屈泽华卜娟
Owner FUDAN UNIV
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