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A method and system for monitoring and/or assessing pupillary responses

A pupil, a series of technologies, applied in the field of pupil response of the eye to light stimuli, can solve the problems of human imaging technology, expensive and limited detection methods, etc.

Inactive Publication Date: 2017-09-26
SINGAPORE HEALTH SERVICES PTE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Early detection of diabetic eye dysfunction is critical to avoid blindness, but the problem is that patients don't complain of vision loss until the disease is advanced
Furthermore, current detection methods based on clinical examination or image analysis are expensive, requiring human labor, appropriate imaging techniques, and expensive software
[0006] Abnormal pupillary responses are observed in glaucoma and other eye diseases affecting optic nerve function and photoreceptor cells in the outer retina (US 7334895; Kardon et al., 2010; Kankipati et al., 2011; Ortube et al., 2013), but These studies are preliminary in nature, for example, evidence is limited on whether pupillary response correlates with disease severity

Method used

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  • A method and system for monitoring and/or assessing pupillary responses
  • A method and system for monitoring and/or assessing pupillary responses
  • A method and system for monitoring and/or assessing pupillary responses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0301] Reduced pupillary response to high-irradiance blue light associated with glaucomatous visual field loss and optic disc depression

[0302] summary

[0303] design: Cross-sectional study.

[0304] Participants: Forty patients with mild to severe glaucoma and 161 control patients aged 50 and older without eye disease were included.

[0305] method: Patients were exposed to 2 minutes of progressively increasing blue (469 nm) or red (631 nm) light stimuli designed to sequentially activate the intrinsic light responses of rods, cones, and melanin-containing retinal ganglion cells. Light is directed to one eye using a modified Ganzfeld dome with an LED light source. Record the diameter of the pupil using an infrared pupillometry system.

[0306] Key Outcome Measures: Through a wide range of corneal irradiance (7 ~ 14 log photon cm -2 the s -1 ) to construct dose-response curves to compare pupillary constriction responses to blue and red light between controls a...

Embodiment 2

[0332] Differentiate between early, moderate and severe glaucoma

[0333] Using a slightly modified color pupillometry and analysis method previously described in Example 1, 29 patients (50 years and older) with early glaucoma, 14 patients with moderate glaucoma, and 12 patients with severe glaucoma (all 50 years and older), examine the pupillary constriction response to blue and red light. In this case, light levels between 8.5 and 14.5 log photons cm -2 the s -1 gradually increased, and subjects were always exposed to blue light first. The pupillary constriction responses of these three groups of patients were compared to those of a group of 39 control subjects (50 years and older) exposed to the same light levels.

[0334] At lower irradiance, there was no difference in pupillary constriction between any patient group for blue and red light stimuli ( Figure 5 A-B). When the irradiance of both colors of light exceeds 11 logarithmic photons cm -2 the s -1 , the resp...

Embodiment 3

[0336] Normal Tension Glaucoma (NTG)

[0337] The pupillary constriction response was examined according to Example 2 in 26 patients (50 years and over) with normal tension glaucoma. In these patients, the optic nerve and retina are damaged, similar to those seen in patients with glaucoma due to increased intraocular pressure. However, in normal tension glaucoma (NTG), normal intraocular pressure can make detection of symptoms more difficult. However, with timely medical treatment, disease progression may be slowed or stopped. Thus, the present invention was used to examine changes in the pupillary constriction response caused by changes in the optic nerve observed with normal intraocular pressure.

[0338] The magnitude of the pupillary constriction response differed between control and NTG patients to gradually increasing blue and red light. At lower irradiance, there was no difference between groups in pupil constriction for blue and red light stimuli ( Figure 6 A-B)...

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Abstract

The present invention relates to a method for monitoring and / or assessing pupillary responses to a continuous illumination of light starting at a first intensity which is gradually changed to subsequent intensity over a predefined period of time. The method may be used to detect aberrant pupillary responses. Also included is a system comprising a light source with adjustable light intensity configured to expose one eye of a subject only or each of the eyes of the subject separately, to a continuous illumination of light starting at a first intensity which is gradually changed to a subsequent intensity over a predefined period of time; and a measuring device configured to measure a parameter associated with said eye's pupil response to the change in intensity of the continuous illumination of light at a succession of times over the period of time, to obtain a profile representing the pupillary response of said eye to the change in intensity of the continuous illumination of light corresponding to the succession of times over the predefined period of time.

Description

technical field [0001] The present invention relates to a method and system for monitoring and / or evaluating the pupillary response of a subject's eyes to light stimuli. Background technique [0002] Vision is probably the most important sense. Although the anterior portion of the eye is transparent to allow visual inspection and imaging of the retina and optic nerve head, various conditions affecting the optic pathway can be difficult to diagnose, especially in the early stages. The concept of early detection or diagnosis is crucial when considering treatment strategies for various ophthalmic diseases affecting the optic pathway, such as diabetic retinopathy or glaucomatous neuropathy, which represent the Two major causes of blindness in the world. With the rapid increase in the number of elderly patients in the world, the morbidity associated with these ophthalmic diseases will increase, resulting in increased medical costs and economic burden. Early detection or diagno...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B3/11A61B3/14
CPCA61B3/112A61B3/14
Inventor 达恩·米利约书亚·詹姆斯·古利
Owner SINGAPORE HEALTH SERVICES PTE