A kind of preparation method of single particle size polymer micro-nano particles

A technology of micro-nanoparticles and polymers, applied in the field of preparation of micro-nanoparticles, can solve problems such as low output, inability to produce large-scale continuous production, easy blockage of pipelines or liquid leakage, etc.

Active Publication Date: 2019-09-20
SOUTH CHINA NORMAL UNIVERSITY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The operation requirements of microfluidic method are relatively high, the output is low, and the pipeline is easy to block or leak, so it cannot be mass-produced continuously

Method used

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  • A kind of preparation method of single particle size polymer micro-nano particles
  • A kind of preparation method of single particle size polymer micro-nano particles
  • A kind of preparation method of single particle size polymer micro-nano particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]In the study of polymer self-assembly, polyethylene glycol-polylactic acid block copolymers are the most typical, because the main chain is soft and easy to assemble.

[0042] Take 1.000g CH 3 O-PEG 1000 -OH in a 50mL three-neck reaction flask. Dry under vacuum at 60°C for 2 hours. After cooling to room temperature, add a small amount of stannous octoate dropwise under the protection of Ar, continue vacuum drying for 30 minutes, add 2.5 g of D-lactide and 5 mL of ultra-dry toluene as solvent under the protection of Ar, and heat to reflux in an oil bath at 120 ° C for 12 h . After the reaction, drop the toluene solution of the product methoxypolyethylene glycol-polylactic acid into frozen anhydrous ether for reprecipitation, collect it into a 50mL centrifuge tube, and centrifuge at 10000rpm for 2min to remove the upper liquid and keep the bottom solid . Then it was dissolved in dichloromethane, reprecipitated in frozen anhydrous ether for the second time, centrifuged...

Embodiment 2

[0050] Take 1.000g CH 3 O-PEG 1000 -OH in a 50mL three-neck reaction flask. Dry under vacuum at 60°C for 2 hours. After cooling to room temperature, add a small amount of stannous octoate dropwise under the protection of Ar, continue vacuum drying for 30 min, add 5 g of D-lactide and 7.5 mL of ultra-dry toluene as solvent under the protection of Ar, and heat to reflux in an oil bath at 120 °C for 12 h . After the reaction, drop the toluene solution of the product methoxypolyethylene glycol-polylactic acid into frozen anhydrous ether for reprecipitation, collect it into a 50mL centrifuge tube, and centrifuge at 10000rpm for 2min to remove the upper liquid and keep the bottom solid . Then it was dissolved in dichloromethane, reprecipitated in anhydrous ether for the second time, centrifuged and vacuum-dried to obtain the final sample.

[0051] Dissolve methoxypolyethylene glycol-polylactic acid in tetrahydrofuran to obtain a polymer solution with a concentration of 50 mg / mL...

Embodiment 3

[0054] Take 1.000g CH 3 O-PEG 1000 -OH in a 50mL three-neck reaction flask. Dry under vacuum at 60°C for 2 hours. After cooling to room temperature, add a small amount of stannous octoate dropwise under the protection of Ar, continue vacuum drying for 30 minutes, add 2.5 g of D-lactide and 5 mL of ultra-dry toluene as solvent under the protection of Ar, and heat to reflux in an oil bath at 120 ° C for 12 h . After the reaction, drop the toluene solution of the product methoxypolyethylene glycol-polylactic acid into frozen anhydrous ether for reprecipitation, collect it into a 50mL centrifuge tube, and centrifuge at 10000rpm for 2min to remove the upper liquid and keep the bottom solid . Then it was dissolved in dichloromethane, reprecipitated in anhydrous ether for the second time, centrifuged and vacuum-dried to obtain the final sample.

[0055] Dissolve methoxypolyethylene glycol-polylactic acid in tetrahydrofuran to obtain a polymer solution with a concentration of 50 ...

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Abstract

The invention belongs to the technical field of preparation of micro-nano particles, and discloses a method for preparing polymer micro-nano particles with a single particle size, comprising the following steps: S1, dissolving an amphiphilic copolymer in an organic solvent to obtain a polymer solution; S2, Coating the polymer solution on the surface of the hydrophobic insulating layer of the electrowetting device, and forming a polymer film after the solvent volatilizes; S3, adding water to the surface of the polymer film to induce polymer segment rearrangement, and waiting for the water to evaporate naturally; S4 1. Add water into the electrowetting device, apply a voltage between the water phase system and the conductive substrate of the electrowetting device, and then remove the water to obtain polymer micro-nano particles with a single particle size. The invention can quickly and effectively prepare polymer micro-nano particles with a single particle size through electrowetting, and the particle size deviation is within ±5nm.

Description

technical field [0001] The invention belongs to the technical field of preparation of micro-nano particles, in particular to a method for rapidly preparing single-diameter polymer self-assembled micro-nano particles by using the principle of electrowetting. Background technique [0002] Nanoparticles have specific surface effects, quantum size effects, small size effects, and macroscopic quantum tunneling effects, so they have extremely important applications in photonic materials, electronic devices, biosensors, and catalysts. [0003] Amphiphilic copolymers can self-assemble into a series of different nano-sized aggregates in selective solutions. The morphology generated by self-assembly can be controlled by many parameters, such as the chemical composition of the copolymer, the pH value of the solution, temperature, the length of the block, the choice of co-solvent and selective solvent, and the relationship between solvent and hydrophobic block. Interfacial tension and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08L67/04
Inventor 李皓侯嘉欣李楠周国富
Owner SOUTH CHINA NORMAL UNIVERSITY
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