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Individualized intervention formula food for diabetes and preparation system thereof

A technology of formula food and preparation system, which is applied in food ingredients, functions of food ingredients, food science, etc., can solve problems such as the inability to directly reduce blood sugar levels and insulin sensitivity in diabetic rats, and achieve control of blood sugar levels and improve life. quality effect

Inactive Publication Date: 2017-10-17
上海利康精准医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

TGP can increase insulin sensitivity and improve lipid metabolism: TGP can significantly improve insulin sensitivity in type 2 diabetic rats, and at the same time significantly improve the disorder of biological sugar and lipid metabolism in diabetic rats, but TGP cannot directly reduce the lipid metabolism in diabetic rats. blood sugar level
It is speculated that it may have an improvement effect on the decreased insulin sensitivity caused by SLC30A8 gene mutation

Method used

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  • Individualized intervention formula food for diabetes and preparation system thereof
  • Individualized intervention formula food for diabetes and preparation system thereof
  • Individualized intervention formula food for diabetes and preparation system thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Detection of Gene Variation

[0047] Individual oral epithelial cell samples were collected, and genomic DNA was extracted by silica gel adsorption method. After electrophoresis detection and verification, fluorescent quantitative PCR reaction was performed.

[0048] Individual samples were put into three reaction wells, and three loci were detected simultaneously, namely, rs2241766 of the ADIPOQ gene, rs13266634 of the SLC30A8 gene, and rs1800795 of the IL-6 gene. In addition, NTC blank control wells without DNA templates were added according to the experimental needs;

[0049] Add reagents to each reaction well as a fluorescent quantitative PCR reaction system with a total volume of 10 μL, that is, 2 μL of DNA template with a concentration of 20 ng / μL, 10× fluorescent quantitative PCR reaction buffer ABITaqman ® MGB 1 μL, 25mM dNTP four deoxynucleotide substrates for DNA synthesis 0.1 μL, 25mM MgCl 2 Solution 0.5μL, (5units / μL) TaqDNA polymerase 0.02μL, de...

Embodiment 2

[0054] Example 2 Assessing the Risk of Variation in the Detected Gene

[0055] According to the relevant research results of molecular epidemiology in a large-scale Chinese population, the risk of different genotypes of the three loci measured in the embodiment is shown in Table 2 below:

[0056] Table 2

[0057] genetic polymorphism site

genotype

Risk (OR)

rs2241766 ( ADIPOQ )

Subtype 1 (GG)

4.23

Subtype 2 (GT)

0.46

Subtype 3 (TT)

0.46

rs13266634 ( SLC30A8 )

Subtype 1 (CC)

5.02

Subtype 2 (CT)

0.73

Subtype 3 (TT)

0.73

rs1800795 (IL-6 )

Subtype 1 (GG)

3.64

Subtype 2 (GC)

3.64

Subtype 3 (CC)

0.58

[0058] Each genetic polymorphism site associated with diabetes has three subtypes, and the possible permutations and combinations of all subtypes of the selected sites are combined; then the risk of these subtypes is multiplied to obtain ...

Embodiment 3

[0068] Example 3 Preparation and administration of individualized intervention formula food

[0069] (1) Raw material preparation

[0070] The relevant raw materials were prepared according to the data in Table 5 below, in which various traditional Chinese medicines came from the Zhonghetang Clinic.

[0071] Table 5 Individualized intervention food formula 1

[0072]

Raw material (by weight)

Basic formula Jiangtang formula

40-60 parts by weight of Radix Astragali, 10-20 parts by weight of Phellodendron Phellodendri, 20-30 parts by weight of Chinese yam, 10-20 parts by weight of Anemarrhena, 20-30 parts by weight of Trichosanthus trichosanthes, 10-20 parts by weight of Dendrobium, 8-14 parts by weight of Schisandra chinensis, Almonds 10~20 parts by weight

Gene hypoglycemic formula

1-5 parts by weight of wolfberry, 20-30 parts by weight of raw land, 10-20 parts by weight of coptis

Gene Hypoglycemic Recipe Supplement

Radix Paeoniae ...

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Abstract

The invention provides an individualized intervention formula food for diabetes and a preparation system thereof. The individualized intervention formula food for the diabetes is prepared by the following steps: 1), determining diabetes-related gene polymorphism sites which are effective for nutrient intervention; 2), detecting mutation of individual ADIPOQ gene, SLC30A8 gene and IL-6 gene; 3), evaluating mutation risk of the detected genes; and 4), determining addition amounts of various ingredients in the individualized intervention formula food, and preparing a corresponding individualized intervention formula food by using a preparation unit of the individualized intervention formula food. The individualized intervention formula food for the diabetes provided by the invention is capable of effectively reducing blood glucose level of patients with the diabetes.

Description

technical field [0001] The invention relates to an individualized intervention formula food, in particular to an individualized intervention formula food for diabetes based on nutritional genomics. Background technique [0002] Diabetes Mellitus (DM) is a group of clinical syndromes caused by the long-term interaction between genetic factors and environmental factors and the biological action of target tissue cells on insulin. DM patients are often accompanied by relative or absolute deficiency of insulin secretion. According to the etiology, diabetes can be divided into 4 categories: type I diabetes, type II diabetes (Type 2diabetes mellitus, T2DM), special type diabetes and gestational diabetes. Among them, type 2 diabetes (type 2diabetes mellitus, T2DM) accounts for about 90%-95% of the total number of diabetics. It is a polygenic genetic disease caused by insulin resistance and pancreatic β-cell dysfunction, and is also affected by environmental factors. . Its pathogen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00
CPCA23V2002/00A23L33/00A23V2200/328
Inventor 袁重庆陆婧毛丹丹傅咏南王校
Owner 上海利康精准医疗技术有限公司
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