Pharmaceutical composition with effect of reversing DDP resistance

A drug and drug resistance technology, applied in drug combination, antineoplastic drugs, pharmaceutical formulations, etc., can solve the problem of multidrug resistance limiting the therapeutic effect of chemical drugs

Inactive Publication Date: 2017-10-20
天津中医药大学第一附属医院
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Problems solved by technology

Chemotherapy plays an important role in the comprehensive treatment of lung cancer. Although new chemotherapeutic drugs are constantly coming out and chemotherapy regimens are becoming more and more perfect, the multidrug resistance (MDR) of tumor cells severely limits the therapeutic effect of chemotherapeutic drugs.

Method used

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  • Pharmaceutical composition with effect of reversing DDP resistance
  • Pharmaceutical composition with effect of reversing DDP resistance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0011] Example: Observation of the regulation of multidrug resistance genes in cisplatin-resistant human lung adenocarcinoma A549 / DDP cells

[0012] 1 Materials and methods

[0013] 1.1 Drugs: It consists of 15g of Astragalus membranaceus and 6g of Hedyotis diffusa two flavors of traditional Chinese medicine. It is decocted in water to concentrate a medicinal solution equivalent to 1.5g / mL of the original medicinal material, cooled and put into a sterilized medicine bottle, and placed in a 4°C refrigerator for later use.

[0014] 1.2 Animals and grouping: SPF grade healthy BalB / C male nude mice, 60, 4-6 weeks old, body weight 18-20g, provided by the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army, animal license number SCXK-(military ) 2014-0004.

[0015] 1.3 Cell lines: human lung adenocarcinoma cell line A549, cisplatin-resistant (DDP) lung adenocarcinoma cell line.

[0016] 1.4 Establishment of subcutaneous xe...

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Abstract

The invention provides a pharmaceutical composition for reversing cisplatin resistance, which comprises astragalus and Hedyotis diffusa as active ingredients. Wherein, the ratio by weight of raw medicinal materials of Astragalus and Hedyotis diffusa is: 9-30 parts of Astragalus, 3-30 parts of Hedyotis diffusa; preferably 12-20 parts of Astragalus, 5-15 parts of Hedyotis diffusa; More preferably 15 parts of Radix Astragali, 10 parts of Hedyotis diffusa.

Description

technical field [0001] The invention relates to a drug combination for treating tumors, which can reverse cisplatin drug resistance. technical background [0002] At present, the morbidity and mortality of lung cancer rank first among malignant tumors in the world. Chemotherapy plays an important role in the comprehensive treatment of lung cancer. Although new chemotherapeutic drugs are constantly coming out and chemotherapy regimens are becoming more and more perfect, the multidrug resistance (MDR) of tumor cells severely limits the therapeutic effect of chemotherapeutic drugs. According to statistics, the death of more than 90% of tumor patients receiving chemotherapy is related to drug resistance. Therefore, the research on the mechanism, detection method and reversal method of MDR has always been the focus in the field of tumor treatment. Contents of the invention [0003] The object of the present invention is to provide a pharmaceutical composition for treating tumo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/748A61P35/00
CPCA61K36/748A61K36/481
Inventor 张莹李小江贾英杰
Owner 天津中医药大学第一附属医院
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