Dialysate regeneration method and blood purification system

A blood purification and dialysate technology, applied in dialysis systems, peritoneal dialysis, blood circulation treatment, etc., can solve the problems of easy decomposition and inactivation of urease, inconvenient operation, complex system, etc., to achieve convenient use, avoid acid-base and ion concentration , The effect of simple system structure

Inactive Publication Date: 2017-10-20
李建中
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are at least three defects in this scheme: 1) urease and ammonium ions are highly hazardous substances, which will cause serious consequences when entering the body; 2) urease is easy to decompose and inactivate, and the conditions for material preparation, storage and use are harsh; 3) zirconium phosphate Adsorbed cations will release sodium ions and hydrogen ions, resulting in the acid-base and ion imbalance of the dialysate, requiring an additional control system to adjust the acid-base and ion concentrations to a physiological range, resulting in a complex system that is not easy to control
However, there is still a risk of ammonium ion leakage during use, and urease is also a highly toxic substance, all of which cause potential risks in treatment
On the other hand, zirconium phosphate adsorbs ammonium ions and releases sodium ions and hydrogen ions at the same time, resulting in an imbalance in the acid-base and ion balance of the dialysate, which requires a complex control system to correct
Therefore, the technology has a large defect

Method used

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  • Dialysate regeneration method and blood purification system
  • Dialysate regeneration method and blood purification system
  • Dialysate regeneration method and blood purification system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A blood purification system such as image 3 As shown, it includes dialyzer 108, ultrafiltration pump 102, power pump 101, first heat exchanger 201, adsorption column 109, second heat exchanger 201, infusion pump 103 connected in series in sequence; 108, so that the dialysate enters the dialyzer 108 for exchange treatment after passing through the infusion pump 103; the first heat exchanger 201 and the second heat exchanger 201 are respectively connected with a refrigeration pump 401 and a heat pump 402; the adsorption column 109 can be set as Two or more in series or in parallel; when the blood purification system is in operation, multiple adsorption columns 109 can work simultaneously or switch regularly. When multiple adsorption columns are switched regularly, one or more of them can be regenerated by flushing with hot aqueous solution.

[0053] The working process of the blood purification system: after the dialysate is exchanged with the blood in the dialyzer 108,...

Embodiment 2

[0060] A blood purification system is the same as that in Embodiment 1.

[0061] The blood purification system is used for blood purification treatment, and the cow blood is placed at the blood end, and the flow rate is 100mL / min. Dialysate, the flow rate is 100mL / min. After the dialysate is exchanged with the simulated fluid, it enters the regeneration system through the power pump 101 . The dialysate first enters the refrigeration exchanger 201, the temperature drops from 37°C to 8±0.5°C, and then enters the adsorption column 109. After the dialysate passes through the second heat exchanger 201, the temperature is heated from 8°C to 37±0.5°C, and returns to to the dialyzer for exchange with blood. Blood, dialysate inlet and outlet samples were taken respectively, and the concentration changes of each component were detected. The results are shown in Table 2 and Figure 8 .

[0062] In this embodiment, two adsorption columns 109 are connected in parallel, and each is fill...

Embodiment 3

[0066] Prepare 1L of dialysate, keep the temperature at 25°C, and use a peristaltic pump to flow through the adsorption column (filled with 100g of activated carbon and 10g of sodium polystyrene sulfonate), and detect the concentration changes of the components in the effluent. The results are shown in Table 3.

[0067] Related parameters of the activated carbon: BET specific surface area 2300m 2 / g, micropore volume: 1.35cm 3 / g, average pore diameter: 2.7nm.

[0068] Table 3 adopts simulation liquid experiment (3L) result

[0069]

[0070]

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PUM

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Abstract

The invention discloses a dialysate regeneration method and a blood purification system. A porous adsorbing material is utilized to conduct adsorption treatment on dialysate, the influence on dialysate components is small, a complicated acid-base and ion regulating control system is avoided, the regenerated dialysate can be cyclically used for hematodialysis or peritoneal dialysis or other blood purification, and various blood purification modes are achieved. Due to the simple technical scheme, the whole size and weight of a dialysis device are greatly decreased, and wearable or portable treatment can be achieved.

Description

technical field [0001] The invention relates to the field of blood purification, in particular to a dialysate regeneration method and a blood purification system. Background technique [0002] Blood purification therapy removes toxins and waste from the body, controls electrolyte and pH balance, and removes excess fluid from the body. It is an effective treatment for organ failure, loss, or replacement. In the process of traditional blood purification treatment, the dialysate is exchanged with blood or body fluid at one time. The dialysis process requires continuous clean water. In order to achieve the effect of completely removing toxins, a treatment needs about 60-200L of water. A large amount of waste liquid will be generated. By regenerating the dialysate, the dialysate can be recycled, which can save a lot of water and cost, reduce the volume of the dialysis machine, and realize portable or wearable treatment. [0003] The dialysate regeneration scheme in the prior ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16A61M1/36A61M1/28
CPCA61M1/1656A61M1/1607A61M1/1696A61M1/287A61M1/3621
Inventor 刘自军李建中
Owner 李建中
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