The invention provides a device capable of realizing automatic simulation of gastrointestinal continuous digestion and an application method of the device. The device comprises a stomach reactor, a stirrer, a constant-temperature water circulation system, a gastrointestinal fluid conveying system, a gastric emptying control device, an automatic pH titration device, a small intestine reactor and asample receiving device. According to the application method, to-be-digested food is conveyed into a stomach digester, stomach digestive fluid is input at a constant speed, the stirrer simulates stomach peristalsis, a micropore glass plate at the bottom of the stomach reactor simulates a pylorus to realize stomach "sieving emptying", the to-be-digested food is conveyed into a pH regulation chamberfor automatic pH regulation, small intestine digestion is simulated in the small intestine reactor provided with an internally-arranged latex sleeve, and the pressure-changing water circulation system is adopted to realize regular vibration of the latex sleeve so as to simulate the stomach peristalsis. Through the device and the application method, the whole reaction process can be continuous andautomatic under the situation that parameters are set; and moreover, the device is simple in structure, free of a complicated control system and easy to assemble and can be used to realize a digestion simulation experiment in a scientific research experiment.