Method and device for calculating additional contribution of genotype to phenotype

A genotype and phenotype technology, applied in the field of bioinformatics, which can solve problems such as inability to obtain

Active Publication Date: 2020-06-23
杭州祥音医学检验实验室有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the external performance traits of organisms, that is, the additional contribution of genotype to phenotype, is still not available.

Method used

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  • Method and device for calculating additional contribution of genotype to phenotype
  • Method and device for calculating additional contribution of genotype to phenotype
  • Method and device for calculating additional contribution of genotype to phenotype

Examples

Experimental program
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Embodiment 1

[0057] see figure 1 , the method for calculating the additional contribution of genotype to phenotype proposed in this embodiment specifically includes the following steps:

[0058] Step S101: Acquiring polymorphic site information through authoritative literature and biological databases, wherein the polymorphic site information includes phenotype, genotype, gene frequency and OR value.

[0059] First of all, it needs to be explained that the additional contribution refers to how many times your contribution is compared to the average group of people. For example, the determination of height is determined by 5 sites, that is, SNP. Then, according to the literature and database, the contribution value of the average population is calculated through an algorithm. Then, through genetic testing of these 5 sites for a person, the person's Genotype, and then through the algorithm to obtain the multiple of the person relative to the average population, the range of the multiple is ...

Embodiment 2

[0076] see figure 2 , image 3 and Figure 4 , the present embodiment provides a device for calculating the additional contribution of the genotype to the phenotype, including: sequentially connected site information acquisition module 1, subdivision module 2, average contribution value calculation module 3, single test module 4 and additional contribution value calculation module 5. When in use, the locus information acquisition module 1 is used to acquire polymorphic locus information through authoritative literature and biological databases, wherein the polymorphic locus information includes phenotype, genotype, gene frequency and OR value, The subdivision module 2 is used to subdivide the species into multiple subcategories according to the phenotypes corresponding to the polymorphic site information, and the average contribution value calculation module 3 is used to calculate the genes in each subcategory according to the gene frequency and OR value The average contrib...

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Abstract

The invention provides a method and device for calculating an additional contribution to a phenotype by a genetype, and relates to technical field of bioinformatics. The method comprises the steps that firstly through authoritative literature and a biological database, gene polymorphism locus information is obtained, wherein the gene polymorphism locus information comprises the phenotype, the genetype, gene frequency and an OR value; then according to the phenotype corresponding to the gene polymorphism locus information, species are divided into a plurality of subgenera; then according to the gene frequency and the OR value, an average contribution value of each genetype of each subgenus is calculated; then single specie to be tested is subjected to gene polymorphism locus detection, and a specific genetype of the specie to be tested is obtained; finally according to the OR value and the average contribution value, a value of the additional contribution to the phenotype by the genetype is calculated. According to the method, the additional contribution to the phenotype by the genetype can be conveniently and rapidly calculated.

Description

technical field [0001] The invention relates to the technical field of bioinformatics, in particular to a method and a device for calculating the additional contribution of genotype to phenotype. Background technique [0002] Gene (also called genetic factor) is the entire nucleotide sequence required to produce a polypeptide chain or functional RNA, which supports the basic structure and performance of life, and is the most basic factor that determines all biological species. Genes determine the birth, old age, sickness and death of people, and are the manipulators and regulators of life. Therefore, the forms of existence and decline of all life are determined by genes. However, due to the influence of the environment, the expression of genes on organisms varies widely. [0003] Genome-wide association study (GWAS) is the application of millions of single nucleotide polymorphisms (single nucleotide polymorphism, referred to as SNP) in the genome as molecular genetic marke...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/20
CPCG16B20/00
Inventor 朱天生范嘉庚刘艳波
Owner 杭州祥音医学检验实验室有限公司
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