Rifaximin uterine injection agent and preparation method and application thereof

A technology of rifaximin and injection, which is applied in the field of rifaximin uterine injection and its preparation and application, can solve the problem of insignificant effect, and achieve the effect of convenient and quick administration, high promotion value and significant curative effect

Inactive Publication Date: 2017-11-10
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in the prevention and treatment of uterine inflammation, there are two major problems that need to be solved urgently: (1) Considering the food safety of milk, it is necessary to choose low-residue drug treatment as much as possible to reduce the time of milk abandonment; (2) clinically, it is mostly Gram Gram-posit

Method used

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  • Rifaximin uterine injection agent and preparation method and application thereof
  • Rifaximin uterine injection agent and preparation method and application thereof
  • Rifaximin uterine injection agent and preparation method and application thereof

Examples

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preparation example Construction

[0051] The rifaximin uterine injection provided by the invention is a uniformly distributed preparation, and the specific preparation method comprises the following steps:

[0052] A. Let the vegetable oil (such as neutral soybean oil) cool after filtration and heat sterilization;

[0053] B. Take an appropriate amount of pretreated vegetable oil and add 0.125-1.25 g of glyceryl monostearate;

[0054] C. Heat at 60-80°C for 15-30 minutes, wait for the glyceryl stearate to melt, stir evenly, cool to about 40°C, add 0.125-1.25g of suspending agent (such as Span 80), 0.05-0.5 g of rifaximin (particle size 5-10 μm), then add vegetable oil to a total of 25 g;

[0055] D. Grind evenly to prepare rifaximin uterine injection;

[0056] F. Put the medicine into the injection tube, seal it, sterilize it, inspect it with light, and pack it.

[0057]In the following examples, the detection method of the sedimentation volume ratio of the uterine injection: take 50ml of the test product w...

Embodiment 1

[0060] Embodiment 1, prescription screening of rifaximin uterine injection

[0061] 1. Screening of glyceryl monostearate content in the formula (note: glyceryl monostearate in the table is referred to as glyceride)

[0062] Table 1

[0063]

[0064] The preparation method is as follows:

[0065] 1) Obtain rifaximin aseptic micropowder (particle size: 5-10 μm) by superfinely pulverizing the aseptic rifaximin powder;

[0066] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150° C. for 3 hours), it is placed at room temperature for use;

[0067] 3) Take an appropriate amount of pretreated soybean oil, add glyceryl stearate and suspending agent Span 80; heat and stir (heating at 80°C for 15 minutes), after the glyceryl stearate melts, add rifaxi Bright;

[0068] 5) Grind evenly in a sterile colloid mill to prepare rifaximin uterine injection.

[0069] As can be seen from table 1 result, when the content of glyceryl monostearate is 0.3% (w / w, g / g), ...

Embodiment 2

[0075] Embodiment 2, preparation rifaximin uterine injection

[0076]

[0077] The preparation method is as follows:

[0078] 1) Ultrafine pulverizing the rifaximin aseptic powder to obtain rifaximin aseptic micropowder with a particle size of 5-10 μm;

[0079] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150° C. for 3 hours), it is placed at room temperature for use;

[0080] 3) Take an appropriate amount of pretreated soybean oil (40% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (heating at 80°C for 15 minutes), and wait for glyceryl monostearate to melt , after stirring evenly, cool to 40°C, add Span 80, rifaximin, and add soybean oil to the full amount;

[0081] 4) Grind evenly in a sterile colloid mill to prepare rifaximin uterine injection.

[0082] The property of the obtained rifaximin uterine injection is orange-red to dark red oily suspension.

[0083] The sedimentation volume ratio and sterility test...

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Abstract

The present invention discloses a rifaximin uterine injection agent and a preparation method and application thereof. The rifaximin uterine injection agent comprises the following raw materials and adjuvant materials: 0.05-0.5g of rifaximin, 0.125-1.25g of glycerin monostearate, 0.125-1.25g of a suspending aid and balanced of vegetable oil added to 25g. The preparation method of the rifaximin uterine injection agent comprises the following steps: 1) mixing part of the vegetable oil and the glycerin monostearate, heating and melting to obtain a mixed system; and 2) adding the suspending aid, the rifaximin and the residual vegetable oil into the mixed system, and evenly grinding to obtain the rifaximin uterine injection agent. The preparation method of the rifaximin uterine injection agent is simple, the prepared rifaximin uterine injection agent has the advantages of uniform dispersion, good stability and easy production expanding; compared with liquid injections, the rifaximin uterine injection agent has the advantages of slow drug release speed, high bioavailability, low irritation to local tissues, remarkable clinical curative effect, and extremely high application value.

Description

technical field [0001] The invention relates to a rifaximin uterine injection and a preparation method and application thereof. Background technique [0002] Inflammation in the uterus of dairy cows mainly includes several clinical symptom types such as metritis, clinical endometritis, subclinical endometritis, and pyometra. It is a common reproductive system disease in dairy cows in my country after delivery. estrus and pregnancy, reduce the milk production of dairy cows, induce diseases such as pancreatitis, and even cause the loss of reproductive capacity of dairy cows in severe cases. Some acutely ill cows can also cause sepsis and lead to death, which seriously hinders the healthy development of my country's dairy farming industry. , causing huge economic losses. This type of disease is mainly caused by microbial infection in the postpartum uterus. The main pathogenic bacteria reported in the literature include: Escherichia coli, Staphylococcus epidermidis, Staphylococcu...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/439A61K47/14A61K47/44A61P15/00
CPCA61K9/10A61K9/0034A61K31/439A61K47/14A61K47/44
Inventor 李秀波徐飞刘义明陈孝杰
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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