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Use of carcinoembryonic antigen associated cell adhesion molecule 1 (CECAM1) proteins as serum markers in diagnosis of liver diseases

A technology for liver diseases and uses, applied in the field of kits for diagnosing liver cancer, can solve the problems of high price, impact, and high false negative rate of imaging detection

Inactive Publication Date: 2017-11-14
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0005] However, AFP has a high false negative rate in the early diagnosis of liver cancer. On the other hand, imaging tests are expensive and easily affected by operator experience, making it difficult to distinguish liver cancer from non-malignant hyperplasia. Therefore, it is urgent to discover new specific markers For early diagnosis of liver cancer

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  • Use of carcinoembryonic antigen associated cell adhesion molecule 1 (CECAM1) proteins as serum markers in diagnosis of liver diseases
  • Use of carcinoembryonic antigen associated cell adhesion molecule 1 (CECAM1) proteins as serum markers in diagnosis of liver diseases
  • Use of carcinoembryonic antigen associated cell adhesion molecule 1 (CECAM1) proteins as serum markers in diagnosis of liver diseases

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[0023] The blood samples of the subjects came from the Laboratory Department of Peking Union Medical College Hospital and the Department of Digestive Oncology of 307 Hospital. Blood samples were obtained through the relevant ethics review committee (Hospital / Medical Academy Basic Institute) with informed exemption. For healthy samples, those with normal liver biochemical test values, no history of liver disease, no history of alcoholism, and no other solid tumors; for HBV cases, HBSAG (+) is required under the premise of the above requirements; liver cirrhosis cases are those with liver biopsy or Clinical, laboratory, imaging diagnosis; primary HCC was confirmed by histopathology or two different imaging (ultrasound, computed tomography, magnetic resonance imaging, angiography) showing arterial enhancing lesions. The blood sample was taken from the antecubital vein of the forearm of the 12-hour fasting person. After the sample was collected by venipuncture, the coagulation tub...

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Abstract

The invention relates to use of carcinoembryonic antigen associated cell adhesion molecule 1 (CECAM1) proteins as serum markers in the diagnosis of liver diseases. Specifically, the invention provides use of associative parts of one or more specific binding CECAM1 proteins in preparation of kits for diagnosis and / or prognosis of the liver diseases.

Description

technical field [0001] The present invention relates to the use of CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) as a diagnostic marker for liver diseases. Specifically, the present invention relates to the use of an antibody specifically binding to CEACAM1 in the preparation of a kit for diagnosing liver cancer. Background technique [0002] According to WHO data in 2008, the incidence of liver cancer ranks fifth among all tumors, and its death rate ranks third. It ranks fifth and seventh among common cancers in men and women, respectively. The number of cases is 695,900, and there is an increasing trend year by year. As the main type of liver cancer, hepatocellular carcinoma (HCC) accounts for about 70% to 85% of the whole, see Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer Journal international du cancer 2010, 127(12): 2893-2917. Some early-...

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Application Information

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IPC IPC(8): G01N33/68G01N33/576G01N33/574
CPCG01N33/57438G01N33/57484G01N33/5761G01N33/6896G01N2333/47G01N2800/085
Inventor 秦晓峰张涛幸雯程根宏隋天琪鲁宁
Owner THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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