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Application of adenosine in preparation of estrogenic drugs

A technology of estrogen and adenosine, applied in the field of medicine, can solve the problems of slow conduction of the atrioventricular node

Inactive Publication Date: 2017-11-17
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adenosine can slow the atrioventricular node conduction, block the atrioventricular node reentry pathway, and restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT) (with or without pre-excitation syndrome), while adenosine There is no report on the estrogen-like effects of glucosides

Method used

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  • Application of adenosine in preparation of estrogenic drugs
  • Application of adenosine in preparation of estrogenic drugs
  • Application of adenosine in preparation of estrogenic drugs

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Experimental program
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Embodiment Construction

[0007] The specific embodiment of the present invention will be described in further detail below in combination with experimental data.

[0008] The present invention finds for the first time that adenosine has an estrogen-like effect, and relevant test data are as follows:

[0009] 1 Experimental materials

[0010] 1.1 Experimental drugs

[0011] Adenosine (Solabu A8240).

[0012] 1.2 Experimental animals and cell lines

[0013] Clean-grade Kunming mice, female, 21 days old (just weaned), weighing 9-12 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2016-0011. Human breast cancer cells (MCF-7) were purchased from the Cell Resource Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences.

[0014] 1.3 Instruments and reagents

[0015] Estradiol valerate tablets (Bayer Pharmaceuticals); microplate reader (BIO-RAD 680); ZRD-7080 automatic new blast drying oven (Shanghai Zhicheng A...

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Abstract

The invention relates to an application of adenosine in preparation of estrogenic drugs. Adenosine can be effectively applied to preparation of the estrogenic drugs. According to the technical scheme, the adenosine dosage realizing the estrogen-like effect is not lower than 50 mg / kg / d. The new application of adenosine is developed, adenosine is effectively applied to preparation of the estrogenic drugs, related diseases caused by secretion shortage of estrogen in body are treated, and innovation in drugs is realized.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of adenosine in the preparation of estrogen drugs. Background technique [0002] Phytoestrogens exist in some natural plants and have estrogen-like effects. Phytoestrogens can bind to estrogen receptors and estrogen-related receptors in the body to regulate estrogen receptors bidirectionally, showing estrogen-like activity. When the level of estrogen in the body is low, it has an estrogen-like effect; when the level of estrogen in the body is high, it can inhibit the effect of endogenous estrogen by binding to the estrogen receptor and produce anti-estrogenic activity. Therefore, phytoestrogens are known as natural selective estrogen receptor modulators. Natural phytoestrogens have lower estrogen-like activity than synthetic estrogens, but they cause fewer side effects such as breast cancer and endometrial cancer, and are safer to use. Therefore, the research on phytoes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P5/30
Inventor 郑晓珂曾梦楠李苗张贝贝吴广操司彦坡冯卫生
Owner HENAN UNIV OF CHINESE MEDICINE