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Method for constructing double-layer gene regulation and control network

A technology of gene regulation network and construction method, which is applied in the field of construction of double-layer gene regulation network

Active Publication Date: 2017-11-17
XIDIAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] To sum up, the problems existing in the existing technology are: most of the current researches are conducted on a single miRNA or a single gene in one type of cancer, and there are very few studies on the cooperative regulation of miRNAs or genes in multiple cancers.

Method used

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  • Method for constructing double-layer gene regulation and control network
  • Method for constructing double-layer gene regulation and control network
  • Method for constructing double-layer gene regulation and control network

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Embodiment Construction

[0028] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0029] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0030] Such as figure 1 As shown, the construction method of the double-layer gene regulation network provided by the embodiment of the present invention comprises the following steps:

[0031] S101: Analyze the expression data of important regulatory factors miRNA in the network;

[0032] S102: Selecting miRNAs related to various cancers by using a statistical test method. Measuring the Pearson correlation between miRNAs;

[0033] S103: Sort the miRNAs according to their correlati...

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Abstract

The invention belongs to the technical field of data processing and discloses a method for constructing a double-layer gene regulation and control network. The method comprises following steps: analyzing expression data of an important regulation and control factor miRNA in a network; selecting miRNA relevant to multiple types of cancer by means of the statistics examination method; measuring Pearson correlation among the miRNA; ordering the miRNA according to the correlation and the number of controllable cancer, screening out strongly correlated miRNA and obtaining target genes thereof and interacting relations among the target genes. The present invention discloses the mechanism of gene and miRNA involved in the regulation of biological processes such as cancer and helps to understand the relationship between genes and cancer and other complex diseases and provides reference for the development of biopharmaceuticals and targeted therapy for pan-cancer. Identifying cancer-associated miRNAs and genes can be used to elucidate the mechanisms of cooperation that are involved in the regulation of key factors that influence a variety of cancer processes, cancer risk prediction, and the development of bio-targeted drugs.

Description

technical field [0001] The invention belongs to the technical field of data processing, and in particular relates to a method for constructing a two-layer gene regulatory network. Background technique [0002] Biological network is one of the research hotspots and difficulties in systems biology and computational informatics in recent years. It is a comprehensive network model that studies and describes the functions and relationships of biomolecules at the system level. The normal expression of genes in biological plays a vital role in the system. Therefore, in essence, the structure of a living body composed of a variety of biomolecules and their mutual regulation can be simplified into a gene network. A gene network is a complex biological network composed of a group of genes and their interactions. The same gene can form different network models through different types of interactions with different genes, such as protein interaction network, gene regulatory network, g...

Claims

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Application Information

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IPC IPC(8): G06F19/18
CPCG16B20/00
Inventor 杨利英张莉彬
Owner XIDIAN UNIV
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