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Application of gynesine in preparing drug for in vitro treating echinococcosis granulosa

A technology of echinococcosis granulosus and trigonelline, which is applied in the application field of medicine, can solve problems such as morbidity, death and the like, and achieve the effect of less side effects for humans

Inactive Publication Date: 2017-11-24
吕海龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CE can cause serious morbidity and death if left untreated

Method used

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  • Application of gynesine in preparing drug for in vitro treating echinococcosis granulosa
  • Application of gynesine in preparing drug for in vitro treating echinococcosis granulosa
  • Application of gynesine in preparing drug for in vitro treating echinococcosis granulosa

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Embodiment 1

[0031] Preparation materials: Nrf2 antibody was purchased from Santa Cruz, trigonelline was purchased from Sigma Aldrich (St, Louis, Missouri, USA), trigonelline was dissolved at a concentration of 10 -1 mol / L dimethyl sulfoxide (DMSO) (purchased from Suleibao Company), based on the results of the initial preliminary experiment, the concentration of the extracted trigonelline was diluted according to the corresponding dose, and it needs to be freshly prepared. , the preparation needs to be sterilized by filtration. The RPMI 1640 medium was purchased from Sigma, and the HO-1 and NQO-1 test equipment were purchased from Wuhan Uersen Experimental Equipment Company.

[0032] Collecting and culturing the protocephalic section: extract and collect Echinococcus granulosus from the liver of slaughtered sheep and goats. After the surface of the infected liver is disinfected, put the collected hydatid cyst fluid into a container containing antibiotics (100U / ml pencillin and 100U / ml stre...

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PUM

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Abstract

The invention discloses application of gynesine in preparing a drug for in vitro treating echinococcosis granulosa, relating to the technical field of medicines. The gynesine disclosed by the invention is used for preparing the drug for in vitro treating echinococcosis granulose. The gynesine is a fenugreek plant extract and has slight side effect to a human body.

Description

technical field [0001] The invention relates to the technical field of treating echinococcosis, in particular to the application of trigonelline in the preparation of a drug for treating echinococcosis in vitro. Background technique [0002] Trigonelline, an extract of the leguminous plant Fenugreek, can be widely extracted from plants and is less toxic to humans than chemicals. Trigonelline is a compound that has been claimed to have anti-cancer, anti-migraine, and cholesterol-lowering and anti-diabetic activities. At the same time, it was also reported that trigonelline had a therapeutic effect on type 2 diabetic rats, and oral administration of trigonelline led to a decrease in serum insulin levels. [0003] Cystic echinococcosis (CE) is a worldwide zoonotic disease affecting humans and livestock caused by the larval stage of the parasitic tapeworm Echinococcus, and it is a global public health and economic problem. CE can cause severe morbidity and mortality if left un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455A61P33/10
CPCA61K31/455A61K36/48
Inventor 吕海龙姜玉峰秦文娟
Owner 吕海龙
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