Recombinant Gal-1 allergy environment immunologic tolerance induction model and establishing method

A technology of immune tolerance and method establishment, applied in the medical field, can solve problems such as uncertainty, difficulty in restoring antigen-specific immune tolerance, poor curative effect, etc., and achieve the effect of promoting recovery, inhibiting inflammation, and improving curative effect

Inactive Publication Date: 2017-11-24
SHENZHEN UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] In summary, the problems in the prior art are: diseases caused by abnormal immune tolerance have a significant negative impact on human health and social economy, and the curative effect is not good; restoring antigen specificity in individuals with abnormal immune tolerance However, it is more difficult to res...

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  • Recombinant Gal-1 allergy environment immunologic tolerance induction model and establishing method
  • Recombinant Gal-1 allergy environment immunologic tolerance induction model and establishing method
  • Recombinant Gal-1 allergy environment immunologic tolerance induction model and establishing method

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Embodiment Construction

[0017] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0018] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0019] The recombinant Gal-1 immune tolerance induction model provided by the embodiments of the present invention is:

[0020] Such as figure 1 As shown, the establishment method of the recombinant Gal-1 allergic environment immune tolerance induction model provided by the embodiment of the present invention includes the following steps:

[0021] S101: Establish OVA antigen to establish a food allergy model;

[0022] S102: Mice were treated with a triple agent (SIT plus Gal-1 or / an...

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Abstract

The invention belongs to the field of medical treatment and discloses a recombinant Gal-1 allergy environment immunologic tolerance induction model and an establishing method. The induction model can induce antigen-specificity regulatory T cells out and recover antigen-specificity immunologic tolerance in a body of a patient, so that allergy reaction is inhibited; under allergy reaction environment, a TNF-alpha content in the body is increased, Gal-1 expression is inhibited, and anti-TNF-alpha antibody is applied to improve Gal-1; the Gal-1 can promote LLPC to be differentiated into Breg, and the anti-TNF-alpha antibody, SIT and Gal-1 are jointly applied to promoting antigen-specificity immunologic tolerance to recover.

Description

technical field [0001] The invention belongs to the medical field, and in particular relates to a recombinant Gal-1 allergic environment immune tolerance induction model and a method for establishing it. Background technique [0002] Immune tolerance refers to the specific immune non-response state produced by the body's immune system after accepting the action of a certain antigen. Individuals who have developed immune tolerance to a specific antigen do not develop an immune response or cannot develop an immune response that can be detected by conventional methods after being stimulated by the antigen again. Therefore, the normal immune tolerance mechanism is very important to maintain the health of the body. The mechanism of immune tolerance is still not very clear. Although the international and domestic research on the factors that impair immune tolerance has made rapid progress in recent years, the restoration of the established immune tolerance damage and the recover...

Claims

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Application Information

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IPC IPC(8): A61K49/00
CPCA61K49/0008
Inventor 杨平常刘志强杨贵徐灵芝谢瑞娣
Owner SHENZHEN UNIV
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