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Application of Xiasangju in the preparation of medicines for preventing and treating hand-foot-mouth disease

A technology for hand, foot and mouth disease and summer mulberry, which can be applied to pharmaceutical formulations, antiviral agents, plant raw materials, etc., and can solve problems such as the application of summer mulberry that has not been disclosed in the prior art

Active Publication Date: 2021-08-06
GUANGZHOU XINGQUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no prior art disclosing the application of Xiasangju in the preparation of medicines for preventing and treating hand, foot and mouth disease

Method used

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  • Application of Xiasangju in the preparation of medicines for preventing and treating hand-foot-mouth disease
  • Application of Xiasangju in the preparation of medicines for preventing and treating hand-foot-mouth disease
  • Application of Xiasangju in the preparation of medicines for preventing and treating hand-foot-mouth disease

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Experimental program
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Effect test

Embodiment 1

[0019] 1. Materials

[0020] 1.1 Sample

[0021] Xiasangju extract (batch number: B150301) and Baiyunshan Xiasangju granules (batch number: MA0180) were provided by Guangzhou Baiyunshan Xingqun (Pharmaceutical) Co., Ltd.

[0022] Sample pretreatment method: Accurately weigh 4.38g of Xiasangju extract, add 34.1mL of LPBS, oscillate to fully mix, filter and sterilize with a 0.22μm microporous membrane, and use it as a drug stock solution (1g crude drug amount / mL); Accurately weigh 50g of Xiasangju Granules, add 34.15mL of PBS, shake well, filter and sterilize with a 0.22μm microporous membrane, and use it as a drug stock solution (1g crude drug amount / mL).

[0023] 1.2 Positive control drugs

[0024] Ribavirin injection (Hangzhou Minsheng Pharmaceutical Co., Ltd., product batch number: 1409254).

[0025] Pre-treatment method of positive control drug: take 1 tube of ribavirin injection (1mL), add 99mL of sterilized normal saline, mix well, and dispense it as drug stock solutio...

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Abstract

Through a large number of researches, the present invention finds the application of Xiasangju in the preparation of medicines for preventing and treating hand, foot and mouth disease. The present invention adopts the CPE observation method to measure, and combines the MTT method for verification, and proves that Xiasangju has the ability to inhibit CoxA16 at the cell level in vitro. effect of disease.

Description

technical field [0001] The invention relates to the application field of traditional Chinese medicines, in particular to the application of Xiasangju in the preparation of medicines for preventing and treating hand, foot and mouth disease. Background technique [0002] Hand, foot and mouth disease is an infectious disease caused by enterovirus. CoxA16 is the main pathogen causing hand, foot and mouth disease. Its infection route includes digestive tract, respiratory tract and contact transmission. It mostly occurs in children under 5 years old. It manifests as mouth pain, anorexia, low fever Small herpes or small ulcers appear on the hands, feet, mouth and other parts. In recent years, the morbidity and mortality of HFMD have been on the rise. However, there is no effective vaccine and targeted treatment. [0003] Xia Sangju is included in the fifteenth volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". It is processed fro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61P31/14
CPCA61K36/287A61K36/536A61K36/605A61K2300/00
Inventor 姚江雄方铁铮彭拓华浦俏虹张贤昌张吉凯罗振奎李苑
Owner GUANGZHOU XINGQUN PHARMA
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