Application of mizoribine to preparation of medicine for preventing foot-and-mouth disease virus infection

A technology of foot-and-mouth disease virus and mizoribine, which is applied in the directions of antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as the herd being susceptible to infection

Active Publication Date: 2019-06-11
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vaccines have been effective in controlling FMD. However, the vaccines are only able to produce complete clinical protection 7 days after immunization of animals, and the herds will still be susceptible to infection in the early stages of the disease outbreak.

Method used

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  • Application of mizoribine to preparation of medicine for preventing foot-and-mouth disease virus infection
  • Application of mizoribine to preparation of medicine for preventing foot-and-mouth disease virus infection
  • Application of mizoribine to preparation of medicine for preventing foot-and-mouth disease virus infection

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Experimental program
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Embodiment 1

[0027] 1. Experimental materials

[0028] 1.1 Cells, Animals, Viruses and Drugs

[0029] IBRS-2 cells were preserved by our research group; 3-day-old suckling mice were purchased from the Experimental Animal Farm of Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. FMDV (O / MY98 / BY / 2010 and A / GDMM / CHA / 2013) was preserved and provided by the National Foot-and-Mouth Disease Reference Laboratory; MIZ was purchased from MCE Company and prepared with DMSO.

[0030] 1.2 Reagents

[0031] DMEM, fetal bovine serum FBS, and trypsin medium were purchased from Gibco; MTS detection kit was purchased from Abcam; TRIZOL was purchased from Invitrogen; SYBRPremix Ex Taq Ⅱ The kits were purchased from Bao Bioengineering (Dalian) Co., Ltd.; RIPA lysate, BCA method protein quantification kit, SDS-PAGE gel preparation kit, ECL were purchased from Biyuntian Company; BSA and PVDF membranes were purchased from BioRad Company; Tween-20 and Tween-80 were purchased from...

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Abstract

The invention relates to application of mizoribine to preparation of a medicine for preventing foot-and-mouth disease virus infection, and belongs to the technical field of veterinary medicines. Through the application of the invention, an efficient, safe and quality-controllable anti-foot-and-mouth disease virus drug can be provided for further controlling the transmission of foot and mouth diseases.

Description

technical field [0001] The invention relates to the technical field of veterinary medicines, in particular to the application of mizoribine in the preparation of medicines for preventing foot-and-mouth disease virus infection. Background technique [0002] Foot-and-mouth disease is an acute, febrile and highly contagious cloven-hoofed infectious disease caused by foot-and-mouth disease virus. The World Organization for Animal Health lists it as a legally notifiable animal disease, my country lists it as a first-class animal disease, and foot-and-mouth disease is listed as one of the priority diseases. [0003] FMDV belongs to the genus Foot-and-Mouth Disease Virus of the family Picornaviridae, and has seven serotypes: O, A, C, Asia1 and SAT I-3. The use of vaccines to prevent and control FMD has achieved remarkable results. However, the vaccine can only produce complete clinical protection after 7 days after immunizing animals, and the herd will still be susceptible to infe...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61P31/14
Inventor 常惠芸李世芳龚美娇邵军军赵付荣常艳燕张永光
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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