Shaking platform for piezoelectric drive of wave type bioreactor

A bioreactor and piezoelectric drive technology, applied in the field of shaking platform, can solve the problems of large space occupied by the driving mechanism and complex overall structure of the shaking platform, and achieve the effects of easy sampling and harvesting products, large holding torque, and large adjustment range

Pending Publication Date: 2017-12-01
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the overall structure of the above-mentioned shaking platform is relatively complicated, and the driving mechanism takes up a large space.

Method used

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  • Shaking platform for piezoelectric drive of wave type bioreactor
  • Shaking platform for piezoelectric drive of wave type bioreactor
  • Shaking platform for piezoelectric drive of wave type bioreactor

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Embodiment Construction

[0027] The present invention will be further explained below in conjunction with the accompanying drawings.

[0028] The present invention can be better understood from the following examples. However, those skilled in the art will readily understand that the specific material ratios, process conditions and results described in the examples are only used to illustrate the present invention, and should not and will not limit the present invention described in detail in the claims .

[0029] Such as figure 1 As shown, a piezoelectrically driven rocking platform for a wave bioreactor includes a loading platform 1, a rotating shaft 2, and a piezoelectric transducer 3. The loading platform 1 is used to place a cell culture bag and pass through the rotating shaft 2. Perform reciprocating swinging motion around the central axis of the rotating shaft 2. The piezoelectric transducer 3 is used to convert electrical energy into mechanical vibration energy, and then use the mechanical v...

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Abstract

The invention discloses a shaking platform for the piezoelectric drive of a wave type bioreactor. The shaking platform is only provided with a carrier platform, a rotating shaft, a piezoelectric transducer and a base, wherein the piezoelectric transducer consists of a rectangular metal plate and piezoelectric ceramics stuck on the surface of the rectangular metal plate; an arc-shaped groove is formed in the middle of the long side of the rectangular metal plate, and the surface of the groove is contacted with a rotor of the rotating shaft; the compound vibration of longitudinal vibration and bending vibration of the rectangular metal plate is excited by applying an electrical signal having a phase difference of pi/2, and the elliptical motion of particles occurs on the surface of the groove. The rotor is driven to make reciprocating rotation within a certain angle range by means of friction, and the carrier platform is further driven to swing, so that a wave motion is produced in cell culture fluid, and the mixing of culture and oxygen transfer on the surfaces of gas and liquid are realized. By adopting a piezoelectric drive way, the shaking platform has the characteristics of being simple in wave making way, easy to control and simple in structure, realizing platform attitude power-off self-locking, and the like, and is beneficial to improvement of cell culture efficiency and culture scale.

Description

technical field [0001] The invention relates to the field of biochemical equipment, in particular to a piezoelectrically driven rocking platform for wave bioreactors. Background technique [0002] The wave bioreactor has been developed since 1996. It can be used for large-scale high-density animal cell culture and is an important equipment in the biotechnology pharmaceutical industry. In the wave reactor, the cells and the culture medium are placed in a sterile closed disposable cell culture bag, since the cell culture bag is for one-time use, cross-contamination is avoided. The cell culture bag is placed on the shaking platform and fed with sterile air. The shaking of the platform forms a wave-like movement in the culture medium to achieve uniform mixing of the culture. The shear force generated by the wavy movement is very small, which avoids the damage of the cells during the mixing process. At the same time, the undulating liquid surface of the culture medium continuou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/36C12M1/00H02N2/00
CPCH02N2/00H02N2/004C12M27/16C12M41/00C12M41/48
Inventor 张百亮李晓牛姚志远
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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