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A kind of thyme essential oil solid dispersion and preparation method thereof

A technology for solid dispersion and essential oil, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of poor water solubility and easy volatility of thyme essential oil, and achieves short preparation time. , Low production cost, safe and reliable production

Active Publication Date: 2020-08-18
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at problems such as poor water solubility and volatile nature of thyme essential oil existing in the prior art, the object of the present invention is to provide a solid dispersion of thyme essential oil and a preparation method thereof, which can improve the dissolution rate of thyme essential oil aqueous solution and reduce its volatility, The use of organic solvents is avoided in its preparation, which meets the requirements of green environmental protection

Method used

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  • A kind of thyme essential oil solid dispersion and preparation method thereof
  • A kind of thyme essential oil solid dispersion and preparation method thereof
  • A kind of thyme essential oil solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of solid dispersion with hydroxypropyl-β-cyclodextrin as carrier (1:10)

[0028] Add hydroxypropyl- β -Cyclodextrin (3.0 g) and thyme essential oil (0.3 g), then add 7 stainless steel ball milling beads as grinding media, the diameter of ball milling beads is 10mm, and the filling rate is 58% (filling rate% = (ball volume × number of balls) / the total volume of the ball milling tank), after mixing evenly, the ball milling tank is put into the roller ball mill, the set speed is 135 rpm, and the time is 4 hours. After the ball milling, the powder is obtained, and the powder is passed through a 100 mesh sieve to obtain a solid dispersion of thyme essential oil body. Take an appropriate amount (that is, dissolve the thyme essential oil solid dispersion in water to form a saturated solution) of the powder into a conical flask, add 10 mL of distilled water, and shake it on a shaker at 37°C and 150 rpm for 24 h. After the supernatant was passed throug...

Embodiment 2

[0029] Example 2: Preparation of solid dispersion with disodium glycyrrhizinate as carrier (1:10)

[0030] Add disodium glycyrrhizinate (13.6 g) and thyme essential oil (1.4 g) into a 50 mL ball milling jar, and then add 7 stainless steel ball milling beads as grinding media, the diameter of ball milling beads is 10 mm, and the filling rate is 58% ((ball volume × ball Number) / total volume of the ball milling tank), after mixing evenly, the ball milling tank is put into the roller ball mill, the set speed is 135 rpm, and the time is 4 hours. After the ball milling, the powder is passed through a 100-mesh sieve to obtain the thyme essential oil solid Dispersions. The steps of solubility determination are the same as in Example 1, and the test results show that the solubility of thymol in the prepared thyme essential oil solid dispersion is 6.68 g / L, and the solubility of carvacrol is 7.06 g / L.

Embodiment 3

[0031] Example 3: Preparation of solid dispersion of arabinogalactan as carrier (1:10)

[0032] Arabinogalactan (13.6 g) and thyme essential oil (1.4 g) were added into a 50 mL ball milling jar, and then 7 stainless steel ball milling beads were added as grinding media. number of balls) / total volume of the ball mill), put the ball mill into the roller ball mill after mixing evenly, set the speed at 135 rpm, and set the time for 4 hours. After the ball milling, pass the powder through a 100-mesh sieve to obtain thyme essential oil Solid dispersion. The solubility detection step is the same as in Example 1, and the test results show that the solubility of thymol in the prepared thyme essential oil solid dispersion is 9.02 g / L, and the solubility of carvacrol is 9.46 g / L.

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Abstract

The invention discloses a thyme oil solid dispersion and a preparation method thereof. The thyme oil solid dispersion comprises natural thyme oil and a polymer carrier material, wherein the polymer carrier material is a polysaccharide which abounds in nature. The preparing method of the thyme oil solid dispersion comprises the steps of mixing the thyme oil with the carrier, and then conducting ball-milling in a ball mill to obtain the thyme oil solid dispersion. By forming a molecular mixture through reduction of mechanical force, increasing dispersion uniformity of the drug and the carrier, increasing wettability and the like, the dissolution of the thyme oil is promoted; furthermore, the complex is formed through clathration of the carrier, so that volatilization of the thyme oil is inhibited. The preparation method has the advantages of being simple, easy to implement, low in cost, non-toxic and harmless, and remarkable in effect. The obtained product can be used as an oral or external use type antibacterial agent for animals, can increase the effective dose of the essential oil and mask unpleasant odors which cause food refusal of animals, and has broad market prospects.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a thyme essential oil solid dispersion capable of improving the dissolution rate of an aqueous solution of thyme essential oil and reducing its volatility and a preparation method thereof. Background technique [0002] In modern pig production, due to large-scale feeding and long-term consumption of feed, the pig’s immunity is low and the digestive system is not fully developed, which leads to a significant increase in the incidence and mortality of pig gastrointestinal diseases. Although excessive use of antibiotics can This situation has been significantly improved, but problems such as super-resistant bacteria and antibiotic drug residues in meat have arisen. [0003] Thyme essential oil is a reddish-brown liquid distilled from Thymus vulgaris L. and T.zygis L.rargracilis Boiss. The main components are thymol (30% to 70%) and carvacrol ( 2% ~ 1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K36/53A61K47/28A61K47/40A61K47/32A61K47/36A61P31/04A61P1/00
CPCA61K9/145A61K9/146A61K36/53
Inventor 许文灏姜昕鹏孙成龙张琦红李坚军苏为科
Owner ZHEJIANG UNIV OF TECH