Test strip in matrix distribution, production process of test strip and detection method

Abstract

The invention provides a test strip in matrix distribution, a production process of the test strip and a detection method. The test strip has a rectangular substrate, medicinal blocks are arranged onthe substrate in a matrix form, and the production process of the test strip has two optionable methods, i.e. a twice pasting and thrice cutting method and a point glue injection pasting method respectively. The detection method adopts fixed image acquisition, the test strip substrate broadens and shortens, the medicinal blocks are concentrated together so as to be convenient for immersion and use, as the medicinal blocks are concentrated together, a test strip analyzer can adopts a fixed image acquisition method, thus greatly simplifying the detection mechanism of the test strip analyzer, andreducing the design, production, manufacturing cost of the test strip analyzer.

Description

technical field [0001] The invention relates to a production process and a detection method of an in vitro reagent, in particular to a matrix-distributed test strip and a production process and a detection method of the test strip. Background technique [0002] Test strips are a kind of in vitro diagnostic reagents, commonly used in hospitals and various medical institutions. Due to the constraints of the production process, common test strips are composed of a long strip substrate and a linear arrangement of spaces glued to the substrate. The chemical reagent is composed of multiple square drug blocks. During production, according to the number of drug blocks on the test strip, prepare the same number of rectangular base papers and rectangular substrates, respectively immerse the base papers in different reagents and then dry them. Stick double-sided tape of the same size on one side of each raw paper, cut all the raw paper with double-sided tape into 4mm wide strips of raw...

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Problems solved by technology

[0003] The purpose of the present invention is to design a new test strip to solve the inconvenience of using the test strip and the high cost of related instrument production. The present invention proposes a test strip and a test strip distributed in a matrix. The production process and detection method of the paper strip, compared with the long test paper strips in which the medicine blocks are arranged in a straight line with an aspect ratio greater than 5 times, the shape of the substrate of the test strip proposed by the present invention is rectangular, long The width ratio is less than or equal to 4 times, the drug blocks are arranged on the substrate in the form of a matrix, the number of rows arranged in the horizontal direction is greater than or equal to 2, the number of columns arranged in the vertical direction is greater than or equal to 2, and the drug blocks arranged in each row or column The quantity is greater than or equal to 2, the shape of the medicine block is a regular polygon or a rectangle or a circle, the length of the side or radius is 1-10mm, and the distance between rows and columns of the medicine block is Between 1-5mm; with the change of the shape of the test strip, there are two optional methods for the production process of the test strip, which are two-time pasting, three-time cutting and point-by-point glue pasting; During the production of double pasting and three cutting processes, prepare the same number of rectangular base papers according to the number of medicine blocks on the test strips, respectively immerse the base papers in different reagents and then dry them. Stick double-sided tape of the same size on one side, cut all base paper with double-sided tape into 4mm wide strips of base paper, and press a paper of the same size on the non-adhesive side of the rectangular single-sided tape The template has a plurality of long holes with a width of 4mm and an interval of 2mm in parallel. Press the strips of base paper cut into 4mm wide strips with the adhesive side facing the single-sided adhesive paper into the long holes of the template, and remove the template. On the rectangular single-sided adhesive paper parallel to the sides, there are multiple strips of base paper soaked in different reagents with a width of 4mm and an interval of 2mm. For the surface glue strip, press a template of the same size on the rectangular substrate along the length direction. There are a plurality of long holes with a width of 4mm and an interval of 2mm parallel to the template along the length direction. The surface adhesive strip is pressed into the long strip hole of the template with the adhesive side facing the substrate, and the template is removed, and two or more long single-sided adhesive strips with a width of 4mm and an interval of 2mm are glued on the rectangular substrate in parallel with the length direction, and then The substrate is cut along the direction of the vertical long strip of single-sided adhesive tape, and the number of rows of drug blocks on the cut rectangular substrate is greater than or equal to two columns, and the test paper with matrix distribution is finally produced by pasting twice and cutting three times Strips; when using the point-by-point glue sticking method for production, prepare the same number of rectangular or rolled base papers according to the number of medicine blocks on the test strips, and then immerse the base papers in different reagents and then dry them. After drying, cut all base paper into strips of 4mm width, and use a liquid glue dispenser to dispense glue dots in a matrix on the rectangular substrate. The number of columns is greater than or equal to 2. Cut the long strip base paper impregnated with different reagents into small squares with a length of 4mm and paste them on the glue points at the same time, then cut the substrate, and the rows of drug blocks on the cut rectangular substrate number and number of columns is greater than or equal to 2, by dotted note Glue sticking method finally produces matrix-like distribution of test strips

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