Medicine composition for treating gestational hypertension complicated with preeclampsia

A technology for gestational hypertension and preeclampsia, applied in the field of medicine, can solve problems such as unfavorable patients, blood pressure control, slow onset of effect, etc., and achieve the effects of avoiding adverse reactions, improving antihypertensive effect, and reducing urinary protein.

Inactive Publication Date: 2018-01-19
刘玉莹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, the prescription of the above-mentioned traditional Chinese medicine compound is relatively large, often requires precious medicinal materials such as antelope and bezoar, and the onset of oral administration is slow, which is not conducive to the timely control of blood pressure of patients

Method used

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  • Medicine composition for treating gestational hypertension complicated with preeclampsia
  • Medicine composition for treating gestational hypertension complicated with preeclampsia
  • Medicine composition for treating gestational hypertension complicated with preeclampsia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Oral solution for treating pregnancy-induced hypertension complicated with preeclampsia and its preparation process

[0042] The following is the composition and preparation process of the oral liquid for treating gestational hypertension complicated with preeclampsia.

[0043] 1. Drug prescription

[0044]

[0045] Second, the preparation process:

[0046] (1) Pulverization: Take the prescription amount of medlar, chrysanthemum, Rehmannia glutinosa, wine cornus, Moutan cortex, Chinese yam, Poria cocos, Alisma, and Leiwan, and pulverize them separately, pass through a 40-mesh sieve, and mix to obtain medicinal powder;

[0047] (2) Extraction: add water to the powder obtained in step (1) and decoct twice, add water 6 times the weight of the medicinal powder for the first time and decoct for 6 hours, add water 4 times the weight of the medicinal powder for the second time and decoct for 2 hours, Combine the water decoction and let it cool down;

[0048] (3...

Embodiment 2

[0051] Example 2 Oral granules for treating gestational hypertension complicated with preeclampsia and its preparation process

[0052] The following are the prescription and preparation process of oral granules for treating pregnancy-induced hypertension complicated with preeclampsia.

[0053] 1. Drug prescription

[0054]

[0055] Second, the preparation process:

[0056] (1) Pulverization: Take the prescription amount of medlar, chrysanthemum, Rehmannia glutinosa, wine cornus, Moutan cortex, Chinese yam, Poria cocos, Alisma, and Leiwan, and pulverize them separately, pass through a 40-mesh sieve, and mix to obtain medicinal powder;

[0057] (2) Extraction: add water to the powder obtained in step (1) and decoct twice, add water 6 times the weight of the medicinal powder for the first time and decoct for 6 hours, add water 4 times the weight of the medicinal powder for the second time and decoct for 2 hours, Combine the water decoction and let it cool down;

[0058] (3...

Embodiment 3

[0061] Embodiment 3 Pharmacodynamics study in vivo

[0062] 1. Drugs and their preparation

[0063] 1. Experimental drug: the clear ointment of prescription 1-3 in the embodiment 1 is selected for the experimental drug.

[0064] Comparing drugs:

[0065] Comparative drug 1 and comparative drug 2 were prepared respectively according to the following prescriptions.

[0066]

[0067] The preparation process of contrast drug 1 is as follows:

[0068] (1) Pulverization: Take the prescription amount of medlar, chrysanthemum, Rehmannia glutinosa, wine cornel, Moutan cortex, Chinese yam, Poria cocos, and Alisma chinensis, respectively pulverize, pass through a 40-mesh sieve, and mix to obtain medicinal material powder;

[0069] (2) Extraction: add water to the powder obtained in step (1) and decoct twice, add water 6 times the weight of the medicinal powder for the first time and decoct for 6 hours, add water 4 times the weight of the medicinal powder for the second time and dec...

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Abstract

The invention belongs to the field of medicines and particularly relates to a medicine composition for treating gestational hypertension complicated with preeclampsia. The medicine composition is prepared from fructus lycii, flos chrysanthemi, radix rehmanniae preparata, common macrocarpium fruit, cortex moutan, rhizoma dioscoreae, poria cocos, rhizoma alismatis and omphalia by extracting throughwater decoction and alcohol deposition methods; a preferable preparation of the medicine composition is an oral liquid preparation. The composition is capable of obviously reducing blood pressure andurine protein of rats suffering from the gestational hypertension complicated with the preeclampsia, so that the composition is capable of relieving gestational hypertension symptom and preventing occurrence of eclampsia.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating gestational hypertension complicated with preeclampsia. Background technique [0002] Gestational hypertension is a disease unique to pregnant women, that is, high blood pressure that occurs after 20 weeks of pregnancy. The incidence rate in my country is 9.4%, and the incidence rate reported abroad is about 7% to 12%. The deterioration of the disease will be accompanied by eclampsia, severe convulsions, affecting the health and safety of mothers and infants, and is one of the main causes of maternal and perinatal morbidity and death. [0003] At present, the pathogenesis of pregnancy-induced hypertension is still unclear. Western medicine mainly uses symptomatic treatment for pregnancy-induced hypertension, that is, the use of antihypertensive drugs to relieve symptoms (Guidelines for the diagnosis and treatment of hypertensive disor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P15/00A61P9/12
Inventor 刘玉莹谭志军寇晨光高继友
Owner 刘玉莹
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