A kind of cefpodoxime axetil taste-masking granules and preparation method thereof

Abstract

The invention relates to the field of pharmaceutical preparations, and specifically discloses a taste-masking granule of cefpodoxime axetil and a preparation method thereof. The taste-masking granules are prepared by mixing cefpodoxam-coated pellets and flavor-correcting granules, and the coated pellets have a three-layer structure of a drug-carrying pellet, an isolation layer and a smooth layer from the inside to the outside. There are cefpodoxime axetil products on the market, which produce an unpleasant bitter taste immediately after taking the children, and the taste is extremely unpleasant. The children's medication compliance is poor and the medication needs to be washed with water, which leads to the problem of inconvenience in taking the medicine. In order to improve the compliance of children's medication The bitter taste of the medicine itself is completely covered, and the sweeteners and other ingredients suitable for children are added to remove the bitter taste of the chemical medicine and increase the aromatic smell, which is easy for children to accept and feel happy with the aromatic smell, thus improving the compliance of children taking medicine . In addition to improving children's medication compliance, the prescription also includes special excipients that can be swallowed directly without drinking water, which solves the problem of inconvenience for children to take medicine.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a taste-masked granule of cefpodoxime axetil and a preparation method thereof. Background technique [0002] Cefpodoxime Proxetil (Cefpodoxime Proxetil) is the third generation oral broad-spectrum cephalosporin, which belongs to β-lactam antibiotics. It was developed by Japan Sankyo Company and was first listed in Japan in 1990. , Gabo, Liangbo, Bowoxin, banan, Cepodem, Vantin, chemical name is (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methyl Oxyimino)-acetamido]-3-methoxymethyl-8-oxo-5-thio-1-azabicyclo-[4,2,0]oct-2-ene-2-carboxylic acid isopropyl Oxycarbonyloxyethyl ester. [0003] Cefpodoxime axetil is a prodrug of cefpodoxime, which itself has no antibacterial activity. After oral administration, it is absorbed through the intestinal tract and is hydrolyzed into cefpodoxime by non-specific esterases in the intestinal wall. Cefpodoxime can inhibit the membrane boun...

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Problems solved by technology

[0007] The present invention mainly solves the problem that the existing cefpodoxime axetil product on the market produces unpleasant bitter taste immediately after being taken by children, the mouthfeel is extremely bad, the children's medication compliance is poor, and the medicine needs to be washed with water, which leads to the inconvenience of taking the medicine. The compliance of children's medication completely covers the bitterness of the medicine itself, and adds ingredients such as sweeteners suitable for children to remove the bitterness of chemical medicines and increase the aroma, which is easy for children to accept and feel happy about the aroma, thus improving the quality of life. Children's Medication Adherence

In addition to improving the compliance of children taking medicine, special excipients are also added in the prescription to enable children to swallow the medicine without water, which solves the problem of inconvenient medicine for children.

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