Blood lipid level related single nucleotide polymorphism rs4883263 detecting system and related application

A polymorphism, horizontal technology, applied in the direction of microbial determination/inspection, biochemical equipment and methods, etc., can solve the problem of lack of Asian population research data and so on

Active Publication Date: 2018-02-02
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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Problems solved by technology

However, almost all of these loci were originally identified in populations of European ancestry, and data from studies in Asian populations, especially Chinese populations, are lacking

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  • Blood lipid level related single nucleotide polymorphism rs4883263 detecting system and related application
  • Blood lipid level related single nucleotide polymorphism rs4883263 detecting system and related application
  • Blood lipid level related single nucleotide polymorphism rs4883263 detecting system and related application

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Embodiment 1

[0024] The invention is divided into two stages (preliminary screening stage and verification stage) to respectively detect and analyze the genetic variation related to TC, LDL-C, HDL-C and TG.

[0025] The research population included 47,532 subjects in the first phase and 13,408 subjects in the validation phase. All studies included a total of 61,669 East Asian populations. Each study was approved by the ethics committee of its research institution and the local investigating agency. All participants signed informed consent in writing.

[0026]In the first stage, a meta-analysis of the exome association study was conducted on 47,532 survey subjects in the East Asian population. 47,532 subjects, from China Eye Study (CHES), China Health and Nutrition Survey (CHNS), Fangchenggang Male Health Examination Survey (FAMHES), Guizhou Bijie Type 2 Diabetes Study (GBTDS), Hong Kong University Special Research Program (HKU-TRS) ), Hubei Coronary Heart Disease Study (HuCAD) and Chines...

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Abstract

The invention provides a blood lipid level related single nucleotide polymorphism rs4883263 detecting system and related application, particularly determines relevance between single nucleotide polymorphism rs4883263 and blood lipid level, provides application of reagent materials and/or instruments for detecting polymorphism of a rs4883263 locus in a sample of a to-be-tested individual to preparation of a detecting system for assessment of blood lipid level and/or dyslipidemia risks, and further provides the detecting system for assessment of the blood lipid level and/or the dyslipidemia risks. The detecting system comprises the reagent materials and/or instruments for detecting polymorphism of the rs4883263 locus in the sample of the to-be-tested individual, wherein rs4883263 is remarkably related to HDL-C level, and rs4883263 locus C allele carriers are lower in HDL-C level and higher in dyslipidemia risks than non-carriers.

Description

technical field [0001] The present invention relates to a single nucleotide polymorphism rs4883263 detection system related to blood lipid levels and related applications, specifically, the present invention relates to reagent materials and / or materials for detecting the polymorphism of the CD16 gene rs4883263 site in a sample from an individual to be tested Or the application of instruments and equipment in the preparation of a detection system for assessing blood lipid levels and / or the risk of developing dyslipidemia, and also relates to a detection system for assessing blood lipid levels and / or the risk of developing dyslipidemia. Background technique [0002] A large number of research data show that dyslipidemia is an independent risk factor for coronary heart disease, myocardial infarction, sudden cardiac death and ischemic stroke. It causes hidden, gradual, progressive, systemic and organic damage to the body by accelerating systemic atherosclerosis. Studies have sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156C12Q2600/172
Inventor 顾东风鲁向锋王来元陈恕凤杨彬
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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