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Method for determining severity of hemophilia, blood specimen analyzer and computer readable medium

An analysis device, a technology for hemophilia, which can be used in analysis materials, measurement devices, disease diagnosis, etc., and can solve problems such as difficulty in hemostasis management

Active Publication Date: 2018-02-06
SYSMEX CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For such patients, hemostasis management with coagulation factor preparations becomes difficult, switching to immunotolerance therapy or bypass preparations, etc., and the treatment policy has to be changed

Method used

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  • Method for determining severity of hemophilia, blood specimen analyzer and computer readable medium
  • Method for determining severity of hemophilia, blood specimen analyzer and computer readable medium
  • Method for determining severity of hemophilia, blood specimen analyzer and computer readable medium

Examples

Experimental program
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Effect test

Embodiment approach

[0033] The method for judging the severity of hemophilia includes a step of coagulating a blood sample to obtain a coagulation waveform.

[0034] Examples of blood samples include whole blood and plasma, preferably plasma. The blood sample is preferably a blood sample derived from a patient suspected of having VS-HA. Known anticoagulants commonly used in coagulation tests may also be added to blood samples. As such an anticoagulant, trisodium citrate is mentioned, for example. Before preparation of the measurement sample, the blood sample may be warmed to a temperature suitable for the coagulation reaction (for example, 36° C. to 38° C.).

[0035] The coagulation method of the blood sample is not particularly limited, and it can be performed by methods known to those skilled in the art. For example, a measurement sample can be prepared by bringing a coagulation time measurement reagent into contact with a blood sample, and the blood sample can be coagulated in the measureme...

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PUM

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Abstract

Disclosed is a method for determining the severity of hemophilia, the method including the steps of: coagulating a blood specimen to acquire a coagulation waveform; acquiring an average change rate ofa coagulation rate from the coagulation waveform; and determining the severity of hemophilia in the blood specimen based on the average change rate of the coagulation rate.

Description

【Technical field】 [0001] The present invention relates to a method for judging the severity of hemophilia and a blood sample analyzing device. 【Background technique】 [0002] Hemophilia is a bleeding disorder resulting from congenital deficiency or insufficiency of coagulation factor VIII (FVIII) or coagulation factor IX (FIX). It is called hemophilia A when FVIII is the cause and hemophilia B when FIX is the cause. In hemophiliacs, bleeding symptoms are seen in deep tissues such as joints and muscles, and in severe cases, intracranial hemorrhage also occurs. [0003] The severity of hemophilia is classified based on FVIII activity or FIX activity in the blood. Specifically, taking the FVIII activity or FIX activity of healthy subjects as 100%, patients with an activity of less than 1% were classified as severe, those with an activity of 1% or more and less than 5% were classified as moderately ill, and those with an activity of 5% or more were classified as severe. , les...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/86
CPCG01N33/86G01N2800/224G01N2800/50G01N33/4905G01N21/77G01N21/82G01N35/00584G01N2021/7783G01N2035/0097G01N2333/7454G01N2333/755G01N2800/56G01N2800/7033
Inventor 岛绿伦野上惠嗣松本智子田渊有香新井信夫
Owner SYSMEX CORP
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