Medical Yttrium Phosphate[ 90 the y 32 po 4 ] Carbon microspheres and preparation method thereof

A 90Y32PO4, yttrium phosphate carbon microsphere technology, applied in pharmaceutical formulations, powder delivery, antitumor drugs, etc., can solve the problems of short half-life and long half-life

Active Publication Date: 2020-02-28
CHENGDU NEW RADIOMEDICINE TECH CO LTD
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Yttrium-90 ( 90 Y) and phosphorus-32 ( 32 P) are the two most commonly used therapeutic nuclides in nuclear medicine, both of which can be prepared into radioactive glass microspheres for tumor treatment, yttrium-90 ( 90 Y) The specific activity of glass microspheres is higher, but yttrium-90 ( 90 Y) has a shorter half-life (64h), while phosphorus-32 ( 32 P) The specific activity of glass microspheres is low, but phosphorus-32 ( 32 P) The half-life is longer (about 14d), and each has its own advantages and disadvantages for the treatment of tumors

Method used

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Examples

Experimental program
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Embodiment

[0038](1) Purification of carbon microspheres: Soak in organic solvents such as ethyl acetate, acetone or ethanol to remove fat; soak in dilute sodium hydroxide solution (0.1-0.5mol / L) to remove alkali-soluble impurities, and then repeatedly wash to weak alkali (PH value of 8-10); then soak in dilute nitric acid (0.1mol / L-0.5mol / L) to remove acid-soluble impurities, and wash until the pH value is 1-2.

[0039] (2) 30g of commercially available high-grade pure magnesium hydrogen phosphate (MgHPO 4 ) or aluminum phosphate (AlPO 4 ) sealed in a quartz glass tube placed in a thermal neutron flux higher than 5×10 13 n / cm 2 .s nuclear reactor irradiation, after 31 P(n,r) 32 P generates radioactive magnesium hydrogen phosphate (MgH 32 PO 4 ) or radioactive aluminum phosphate (Al 32 PO 4 ), 32 The nuclear purity of P is not less than 99.9%, and the specific activity is greater than 148GBq(4Ci) / gP. Use HCl solution [the hydrochloric acid solution here uses 36-38% HCl solution ...

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Abstract

A medical yttrium phosphate carbon microsphere for use in tumor treatment and a preparation method therefor. A medical yttrium phosphate carbon microsphere for use in tumor treatment and a preparation method therefor. The medical yttrium phosphate [90Y32PO4] carbon microsphere is prepared with a carbon microsphere being used to adsorb an yttrium tartrate-90 (90Y-tartaric acid) complex produced by reacting 90YCl3 with tartaric acid, then processed with an Na3 32PO4 solution to produce 90Y32PO4 that is then precipitated, solidified, and purified.

Description

technical field [0001] The present invention relates to a tumor radiotherapy drug and a preparation method thereof, in particular to a medical yttrium phosphate [ 90 Y 32 PO 4 ] Carbon microspheres and preparation method thereof. Background technique [0002] Malignant tumor is a disease that seriously endangers human health. Surgical operation, chemotherapy and radiotherapy are the main methods for treating malignant tumors. Since most patients have entered the middle and late stage when their cancer is diagnosed, they have lost the chance of surgical treatment, and they are no longer sensitive to chemotherapy drugs after repeated chemotherapy, so radiotherapy has become a key treatment method for some cancers. For example, liver cancer. In 2015, the estimated number of cases of liver cancer in China was 466,100, and the estimated number of deaths was 422,100. The number of cases and deaths of liver cancer ranked third among all cancers [Wanqing Chen, Jie He , et al. Ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02A61K51/12A61P35/00A61P35/04A61K103/32A61K101/00
CPCA61K9/0019A61K9/0024A61K51/02A61K51/1251A61K51/12A61P35/00A61P35/04
Inventor 李茂良蔡继鸣胡学正葛强
Owner CHENGDU NEW RADIOMEDICINE TECH CO LTD
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