Medical yttrium phosphate [<90>Y<32>PO4] carbon microspheres and preparation method thereof

Abstract

The invention discloses medical yttrium phosphate [<90>Y<32>PO4] carbon microspheres for treating tumors and a preparation method thereof. The medical yttrium phosphate [<90>Y<32>PO4] carbon microspheres are prepared by enabling <90>YCl3 adsorbed by carbon microspheres and a tartaric acid solution to react to generate an yttrium tartrate-90(<90>Y-tartaric acid) complex compound, then treating thecompound with a Na3<32>PO4 solution to generate <90>Y<32>PO4 sediment, and curing and purifying. According to the medical yttrium phosphate [<90>Y<32>PO4] carbon microspheres disclosed by the invention, the adsorption and curing efficiency on yttrium (<90>Y) nuclide is greater than 95 percent, and the adsorption and curing efficiency on phosphorus-32(<32>P) nuclide is higher than 99 percent; afterthe carbon microspheres are further subjected to purification treatment, the releasing rates of the medical yttrium phosphate [<90>Y<32>PO4] carbon microspheres on yttrium-90(<90>Y) and phosphorus-32(<32>P) are both less than 0.01 percent; the medical yttrium phosphate [<90>Y<32>PO4] carbon microspheres have good biocompatibility and can be used for radiotherapy in-vivo tumors.

Description

technical field [0001] The present invention relates to a tumor radiotherapy drug and a preparation method thereof, in particular to a medical yttrium phosphate [ 90 Y 32 PO 4 ] Carbon microspheres and preparation method thereof. Background technique [0002] Malignant tumor is a disease that seriously endangers human health. Surgical operation, chemotherapy and radiotherapy are the main methods for treating malignant tumors. Since most patients have entered the middle and late stage when their cancer is diagnosed, they have lost the chance of surgical treatment, and they are no longer sensitive to chemotherapy drugs after repeated chemotherapy, so radiotherapy has become a key treatment method for some cancers. For example, liver cancer. In 2015, the estimated number of cases of liver cancer in China was 466,100, and the estimated number of deaths was 422,100. The number of cases and deaths of liver cancer ranked third among all cancers [Wanqing Chen, Jie He , et al. Ca...

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Problems solved by technology

[0003] Yttrium-90 ( 90 Y) and phosphorus-32 ( 32 P) are the two most commonly used therapeutic nuclides in nuclear medicine, both of which can be prepared into radioactive glass microspheres for tumor treatment, yttrium-90 ( 90 Y) The specific activity of glass microspheres is higher, but yttrium-90 ( 90 Y) has a shorter half-life (64h), while phosphorus-32 ( 32 P) The specific activity of glass microspheres is low, but phosphorus-32 ( 32 P) The half-life is longer (about 14d), and each has its own advantages and disadvantages for the treatment of tumors