Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Intratumoral injection for treating rhabdomyosarcoma

A technique for rhabdomyosarcoma and injection, applied in the field of intratumoral injection

Active Publication Date: 2018-02-27
张欣
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As of now, there is no report on the antitumor activity of 2,5-dimethoxy-4-iodophenylpropan-2-amine hydrochloride in the literature

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Intratumoral injection for treating rhabdomyosarcoma
  • Intratumoral injection for treating rhabdomyosarcoma
  • Intratumoral injection for treating rhabdomyosarcoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Intratumoral injection for the treatment of rhabdomyosarcoma and its preparation

[0026]

[0027] Preparation:

[0028] Mix danshensu and 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride, add water for injection, stir and dissolve at 20℃~37℃; then add mannitol and sodium acetate, 20℃ Stir and dissolve at ~37°C; filter through a 0.22-micron microporous membrane until clarified, and dispense into ampoules. Wherein the dosage of mannitol is 3 times of the weight of Danshensu, the consumption of sodium acetate is 0.06 times of the weight of Danshensu, and the dosage of 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride in the injection The concentration is 9.6mg / ml.

Embodiment 2

[0029] Example 2 Intratumoral injection for treating rhabdomyosarcoma and its preparation

[0030]

[0031] Preparation:

[0032] Mix danshensu and 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride, add water for injection, stir and dissolve at 20℃~37℃; then add mannitol and sodium acetate, 20℃ Stir and dissolve at ~37°C; filter through a 0.22-micron microporous membrane until clarified, and dispense into ampoules. Wherein the dosage of mannitol is 3 times of the weight of Danshensu, the consumption of sodium acetate is 0.06 times of the weight of Danshensu, and the dosage of 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride in the injection The concentration is 9.8mg / ml.

Embodiment 3

[0033] Example 3 Intratumoral injection for treating rhabdomyosarcoma and its preparation

[0034]

[0035] Preparation:

[0036] Mix danshensu and 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride, add water for injection, stir and dissolve at 20℃~37℃; then add mannitol and sodium acetate, 20℃ Stir and dissolve at ~37°C; filter through a 0.22-micron microporous membrane until clarified, and dispense into ampoules. Wherein the consumption of mannitol is 4 times of the weight of Danshensu, the consumption of sodium acetate is 0.05 times of the weight of Danshensu, 2,5-dimethoxy-4-iodophenylpropane-2-amine hydrochloride in the injection The concentration is 10.0mg / ml.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of medicines, and particularly relates to intratumoral injection for treating rhabdomyosarcoma. The intratumoral injection is prepared from the following componentsin parts by weight: 11-21 parts of tanshinol, 2-5 parts of 2,5-dimethoxy-4-Iodophenyl dimethylmethane-2-amine hydrochloride, and a pharmaceutically acceptable medicinal auxiliary material which is preferably prepared from mannitol, sodium acetate and injection water, wherein the tanshinol has a certain effect for resisting rhabdomyosarcoma; and no anti-tumor effect for a rhabdomyosarcoma cell lineand animal model is found in 2,5-dimethoxy-4-Iodophenyl dimethylmethane-2-amine hydrochloride, but cell and animal experiments indicate that 2,5-dimethoxy-4-Iodophenyl dimethylmethane-2-amine hydrochloride has a remarkable synergistic effect for the rhabdomyosarcoma resistance of tanshinol. The intratumoral injection has excellent safety in intratumoral injection.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an intratumoral injection for treating rhabdomyosarcoma. Background technique [0002] Rhabdomyosarcoma is a malignant tumor originating from striated muscle cells or mesenchymal cells that differentiate into rhabdomyosarcoma. The disease often occurs in children, accounting for about 50% of soft tissue sarcoma in children under the age of 15, accounting for 4% to 8% of all malignant tumors in children (Li Dongliang, Liu Chunxia, ​​Zou Hong, Li Feng. Molecular biology research progress of rhabdomyosarcoma. Clinical Journal of Experimental Pathology. 2011,27(2):181-185.). The incidence rate of adults is low, and the incidence rate of men is higher. It is a kind of soft tissue sarcoma with a higher degree of malignancy, and regional lymph node metastasis and hematologic metastasis are prone to occur. [0003] At present, there are relatively few studies on rhabdomyosarcoma, an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/192A61K31/137A61P35/00
CPCA61K9/0019A61K9/08A61K31/137A61K31/192A61K47/12A61K47/26A61K2300/00
Inventor 张欣姚静王飞
Owner 张欣
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com