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Compound dictyopterisin F and its application in the preparation of antitumor drugs

A technology of anti-tumor drugs and compositions, which is applied in the field of medicine and can solve the problems of unreported anti-tumor activity

Active Publication Date: 2019-11-15
HUNAN STEROL PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reticopterin F is a new compound, and its antitumor activity has not been reported

Method used

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  • Compound dictyopterisin F and its application in the preparation of antitumor drugs
  • Compound dictyopterisin F and its application in the preparation of antitumor drugs
  • Compound dictyopterisin F and its application in the preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation of the Dictyostatin F

[0026] 1. Preparation of Dictyoptera undulata extract extract

[0027] (1) Preparation of extract

[0028] Frozen D. undulata (collected from the coast of Zhanjiang, Guangdong) 1.8 kg (wet weight) was extracted three times by percolation with 5L 95% ethanol for 2 days each time, and the extracts were combined;

[0029] (2) Preparation of extract extract

[0030] Concentrate the above extract at a temperature ≤45°C under reduced pressure to recover ethanol to obtain 174.5 g of crude extract;

[0031] 2. Separation and purification

[0032] 1) Disperse the above crude extract in 2L of water to form a suspension, extract the suspension with ether (1.5L) four times, and concentrate the resulting extract under reduced pressure to obtain the ether extract (54.3g);

[0033] 2) The ether extract is subjected to silica gel column chromatography, followed by a gradient elution of petroleum ether / acetone and dichloromethanol / methanol; the concentr...

Embodiment 2

[0047] Example 2: In vitro anti-tumor activity test of the Dictyostatin F

[0048] Cell lines: human acute promyelocytic leukemia cells (HL-60) and human lung cancer cells (A-549).

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Abstract

The invention relates to the technical field of medicines, and relates to a novel natural medicine having anti-tumor functions and extracted and separated from dictyopteris undulata Holmes in China. The medicine is a steroid compound that is dictyopterisin F. In-vitro anti-tumor activity tests prove that IC50 values of the compound for human acute promyelocytic leukemia cells (HL-60) and human lung cancer cells (A-549) are 2.45 [mu]M and 2.85 [mu]M respectively, and therefore the compound can be used for preparing anti-tumor medicines, can be prepared into anti-tumor medicine compositions withother medicines, and can be prepared into injections, tablets, pills, capsules, solutions, suspensions, emulsions, and other dosage forms with pharmaceutically acceptable auxiliary materials, and administration routes of the compound can be oral administration, intravenous administration, intramuscular administration or percutaneous administration.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a new natural medicine with anti-tumor effect extracted and isolated from the Chinese Dictyopteris undulata Holmes, and the medicine is a new steroid compound dictyopterisin F (dictyopterisin F). Background technique [0002] With the progress of society, the resulting work pressure continues to increase and the global environment continues to deteriorate. The incidence of malignant tumors is increasing year by year, and malignant tumors have become one of the major diseases that endanger human health. According to the latest data released by the World Health Organization (WHO), 8.8 million people die from cancer each year, accounting for nearly one-sixth of the total deaths worldwide. There are more than 14 million new cancer cases each year, and this number is expected to increase to more than 21 million by 2030. Cancer will surpass cardiovascular disease and become the number one ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00A61K31/575A61P35/00A61P35/02
CPCC07J9/00
Inventor 毛水春冯美堂蔡浙飞郭跃伟
Owner HUNAN STEROL PHARM TECH CO LTD