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dispersed lactam

A technology of lactam and solid dispersion, which is applied in the field of lactam and can solve problems such as solubility limitations

Active Publication Date: 2021-07-20
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the use of these lactams is limited by their solubility, especially in aqueous compositions, but also in non-aqueous compositions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0066] The lactams - 4-(4-bromophenyl)-5-hydroxy-5-methyl-1H-pyrrol-2-one and 4-(4-chlorophenyl)-5-methylene were prepared according to - Pyrrol-2-one - solid dispersion in PEG (1.5k, 10k or 20k molecular weight) or polyvinylpyrrolidone (PVP, 40k molecular weight):

[0067] Lactam and polymer (PVP or PEG) were combined in the desired ratio, suspended in acetonitrile and heated to cause dissolution. Thereafter, the solution was cooled to room temperature, and the solvent was removed in vacuo to provide the desired solid dispersion. The material was dried under vacuum for an extended period of time to ensure removal of all residual solvent, and ground to provide a fine powder.

[0068] The inventors have shown that a solid dispersion of a lactam in PVP confers enhanced water solubility to the lactam. As can be seen from the photographs below, both PVP alone and a solid dispersion of 1% lactam in PVP dissolved rapidly in water to provide a clear solution. Lactam in an amount e...

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PUM

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Abstract

The lactam in solid dispersion suitable for use in the composition. The compositions are useful as antimicrobial, antibiofilm and bacteriostatic compositions. Process for the preparation of lactams in solid dispersions. Process for preparing a composition using a lactam in a solid dispersion.

Description

[0001] This application claims priority from EP 15181830.9, filed 20 August 2015, which is incorporated by reference for all purposes. technical field [0002] The present invention relates to lactams in solid dispersion. The lactams in solid dispersion are suitable for use in compositions, for example in antimicrobial, antibiofilm and bacteriostatic compositions. The invention further relates to a method of forming a lactam in a solid dispersion. Background technique [0003] WO 2007 / 085042 and WO 2004 / 016588 disclose lactams for antimicrobial benefit and procedures for their synthesis. WO2014 / 118240 discloses antimicrobial compositions comprising a lactam and a hydrotrope. [0004] However, the use of these lactams is limited by their solubility, especially in aqueous compositions, but also in non-aqueous compositions. Contents of the invention [0005] The present invention relates to lactams in solid dispersion. The use of solid dispersions of lactams allows greate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/49A01N43/36A61Q17/00B08B17/02
CPCA61K8/4913A61Q17/005B08B17/02A61K8/8176A61K8/86A01N43/36A01N25/04A01N25/10
Inventor N·J·帕里P·D·普莱斯S·辛格
Owner UNILEVER IP HLDG BV