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Composition for alleviating alcoholic liver damage and preparation method thereof

A technology for alcoholic liver injury and composition, which is applied in the field of compositions for relieving alcoholic liver injury and the field of preparation thereof, can solve the problems of single action, side effects, insufficient curative effect and the like, and achieve the effect of reducing activity

Active Publication Date: 2018-03-30
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs or health care products currently developed to relieve alcohol and protect the liver often have a single effect, and have not yet played a role in reducing the gastrointestinal digestion and absorption of alcohol and anti-oxidation at the same time, and have defects such as slow effect, insufficient curative effect, and side effects.

Method used

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  • Composition for alleviating alcoholic liver damage and preparation method thereof
  • Composition for alleviating alcoholic liver damage and preparation method thereof
  • Composition for alleviating alcoholic liver damage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The specific preparation method is as follows:

[0023] (1) Preparation of olive juice: peel fresh green olives, wash, remove pits, and homogenate; coarsely filter the homogenate with gauze, and centrifuge the filtrate at a high speed of 3000r / min for 15min; take the supernatant and filter it on filter paper The purer olive juice is obtained, which is ready-to-use.

[0024] (2) Cultivation of rhamnobacteria: cultured with improved MRS medium, using a single sugar source. The formula is as follows: Add 10g peptone, 10g beef extract powder, MnSO4 to 1L distilled water 4 ·H 2 O 0.25g, MgSO 4 ·7H 2 O 0.58g, K 2 HPO 4 2g, Tween 80 1ml, rhamnose 20g, anhydrous sodium acetate 5g, diammonium hydrogen citrate 2g, yeast powder 5g, agar 18.0g. Stir evenly, adjust the pH to 6.2-6.4, and sterilize at 121°C for 30 minutes. Bacteria powder (containing rhamnosus) was first cultivated in a liquid medium (same as the above formulation, but without agar), and then inoculated into...

Embodiment 2

[0027] The specific preparation method is as follows:

[0028] (1) Preparation of olive juice: peel fresh green olives, wash, remove pits, and homogenate; coarsely filter the homogenate with gauze, and centrifuge the filtrate at a high speed of 3000r / min for 15min; take the supernatant and filter it on filter paper The purer olive juice is obtained, which is ready-to-use.

[0029] (2) Cultivation of rhamnobacteria: cultured with improved MRS medium, using a single sugar source. The formula is as follows: Add 10g peptone, 10g beef extract powder, MnSO4 to 1L distilled water 4 ·H 2 O 0.25g, MgSO 4 ·7H 2 O 0.58g, K 2 HPO 4 2g, Tween 80 1ml, rhamnose 20g, anhydrous sodium acetate 5g, diammonium hydrogen citrate 2g, yeast powder 5g, agar 18.0g. Stir evenly, adjust the pH to 6.2-6.4, and sterilize at 121°C for 30 minutes. Bacteria powder (containing rhamnosus) was first cultivated in a liquid medium (same as the above formulation, but without agar), and then inoculated into...

Embodiment 3

[0032] The specific preparation method is as follows:

[0033] (1) Preparation of olive juice: peel fresh green olives, wash, remove pits, and homogenate; coarsely filter the homogenate with gauze, and centrifuge the filtrate at a high speed of 3000r / min for 15min; take the supernatant and filter it on filter paper The purer olive juice is obtained, which is ready-to-use.

[0034] (2) Cultivation of rhamnobacteria: cultured with improved MRS medium, using a single sugar source. The formula is as follows: Add 10g peptone, 10g beef extract powder, MnSO4 to 1L distilled water 4 ·H 2O 0.25g, MgSO 4 ·7H 2 O 0.58g, K 2 HPO 4 2g, Tween 80 1ml, rhamnose 20g, anhydrous sodium acetate 5g, diammonium hydrogen citrate 2g, yeast powder 5g, agar 18.0g. Stir evenly, adjust the pH to 6.2-6.4, and sterilize at 121°C for 30 minutes. Bacteria powder (containing rhamnosus) was first cultivated in a liquid medium (same as the above formulation, but without agar), and then inoculated into ...

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Abstract

The invention discloses a composition for alleviating alcoholic liver damage. The composition for alleviating the alcoholic liver damage comprises a mixture of lactobacillus rhamnosus liquid and olivejuice. The olive juice is obtained by peeling fresh green olives, and carrying out washing, denucleating, homogenating centrifuging, and filtering. The lactobacillus rhamnosus liquid is prepared by the steps that bacterial powder containing lactobacillus rhamnosus is taken, firstly being cultivated in a liquid medium and then inoculated to a solid medium to be cultured at 38 DEG C for 24 h, passaged three times to obtain pure bacteria, and finally transferred into a liquid medium. According to the composition of the invention, natural extracts and probiotics are matched, have no side effectson a body, can reverse righting reflex in alcoholic liver loss model mice and reduce activity of glutamic-pyruvic transaminase and aspartate aminotransferase, which are indexes reflecting hepatocyte loss, in blood to achieve effects of dispeling the effects of alcohol to protect the liver.

Description

technical field [0001] The invention belongs to the technical field of health food, and in particular relates to a composition for alleviating alcoholic liver damage and a preparation method thereof. Background technique [0002] In today's era, alcohol has almost become an indispensable drink on the dinner table, but a series of diseases caused by alcohol are endangering people's health. Modern clinical medical research and clinical research have shown that heavy drinking leads to particularly serious liver damage. Therefore, liver protection has become a topic of increasing concern. Alcoholic liver disease (ALD) is a liver damage lesion that develops due to long-term excessive drinking of alcoholic beverages. Alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, and cirrhosis are all clinical pathological manifestations. These kinds of lesions not only exist alone or together in the liver with lesions, but also often partially overlap. With the improveme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/32A61P1/16C12N1/20C12R1/01A61K35/741
CPCA61K35/741A61K36/32C12N1/20A61K2300/00
Inventor 甘玲龙瑶李康黄庆洲张耕罗献梅陈吉轩伍莉焦寒伟帅学宏
Owner SOUTHWEST UNIV
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