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Application of serum miRNA-4463 as hepatocellular carcinoma diagnosis marker

A miRNA-4463, diagnostic marker technology, applied in the fields of biotechnology and medicine, can solve the problems of misdiagnosis of AFP, negative and elevated AFP, etc., and achieve the effect of good sensitivity and specificity

Inactive Publication Date: 2018-03-30
NANHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Alpha-fetoprotein (AFP) is currently the most widely used tumor marker for the diagnosis of liver cancer, but there are still diagnostic errors in AFP, for example, AFP in some patients with liver cancer is negative or slightly elevated

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  • Application of serum miRNA-4463 as hepatocellular carcinoma diagnosis marker
  • Application of serum miRNA-4463 as hepatocellular carcinoma diagnosis marker
  • Application of serum miRNA-4463 as hepatocellular carcinoma diagnosis marker

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Embodiment Construction

[0051] Below in conjunction with embodiment the present invention will be further described

[0052] Example Collection of serum samples: The experimental group consisted of 45 patients with liver cancer from September 2015 to January 2016 at Nanhua Hospital Affiliated to Nanhua University and First Attached Hospital. The age of the patients ranged from 31 to 80 years old, with an average age of 57.64 years. Each patient with liver cancer was diagnosed by at least two methods of ultrasound, CT and histopathology, combined with relevant medical history and serum AFP level. All samples were collected before the patients underwent treatment. Serum samples from 45 normal individuals in the control group were obtained from the Physical Examination Center of Nanhua Hospital Affiliated to Nanhua University. Volunteers were 28-72 years old, with an average age of 45.22 years. All participants who participated in this experiment signed an informed consent form before the experiment,...

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Abstract

The invention discloses an application of microRNA-4463 as a hepatocellular carcinoma diagnosis marker. Researches in the invention find that the expression level of the microRNA-4463 in the serum ofa hepatic carcinoma patient is obviously higher than that of normal people, and the expression level of the microRNA-4463 in the serum of the hepatic carcinoma patient, with low alpha-fetoprotein (AFP< 400 [mu]g / l), is still high, so the microRNA-4463 plays a great role in the diagnosis of low alpha-fetoprotein hepatic carcinoma. The prognosis of patients can be judged by detecting the expression level of the microRNA-4463. The invention discloses a method for detecting the microRNA-4463 based on the application. The method has a good development prospect and good clinical application values.

Description

technical field [0001] The invention relates to the application of serum microRNA (miRNA-4463) as a diagnostic marker for hepatocellular carcinoma, belonging to the fields of biotechnology and medicine. Background technique [0002] Primary liver cancer is one of the most common malignant tumors in the world, and it ranks third in the world in cancer-related death. It has the epidemiological characteristics of high malignancy, high metastasis rate, high recurrence rate and low survival rate. It seriously endangers people's life and health and becomes a huge challenge to human public health. Due to the hidden early clinical manifestations of liver cancer and the lack of effective early diagnosis, most patients are diagnosed with advanced liver cancer, often accompanied by distant metastasis or intrahepatic metastasis. The prognosis is poor and the survival period is short. Therefore, early detection and diagnosis are of great significance for taking effective treatment in t...

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Application Information

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IPC IPC(8): G01N21/64G01N1/28
Inventor 左建宏文美玲胡甜
Owner NANHUA UNIV