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Hypolycemic pharmaceutical composition and preparation method thereof

A composition and blood sugar-lowering technology, applied in the field of medicine, can solve problems such as insignificant effects of insulin, obvious toxic and side effects, and lack of insulin, and achieve the effects of reducing weight, improving curative effect, and reducing blood lipids

Inactive Publication Date: 2018-04-13
罗昌兴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More than 90% of diabetic patients are type 2 diabetes. The ability to produce insulin in the body of type 2 diabetic patients is not completely lost. Some patients even produce too much insulin in the body. However, due to the enhanced insulin resistance of the body, the effect of insulin is not effective. Obviously, insulin deficiency in patients is therefore a relative deficiency
[0003] At present, the commonly used drugs for the treatment of diabetes include sulfonylureas, biguanides and α-glucosidase inhibitors, all of which have different degrees of defects when used alone, such as large dosage and obvious side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation of a hypoglycemic pharmaceutical composition, the specific steps are:

[0021] Step 1: Take repaglinide 5g, metformin hydrochloride 20g, pioglitazone 5g, sorbitol 15g, micronized silica gel 0.5g, polacrilin potassium resin (IRP88) 4g, stevioside 0.2g and ethanol 8g in a pharmaceutical grade clean area ;

[0022] Step 2: Weigh metformin and water and mix it at a mass ratio of 1:30 to make it completely dissolved, then add polacrilin potassium (IRP88) resin for ion exchange, react for 1 hour, filter and wash with water, and dry at 60°C , to prepare drug-containing resin powder, which is passed through an 80-mesh sieve for subsequent use;

[0023] Step 3: uniformly mix the drug-containing resin powder with repaglinide, pioglitazone, sorbitol, micronized silica gel, stevioside, and ethanol, and press into tablets with a specification of 0.25 g / tablet.

Embodiment 2

[0025] A preparation of a hypoglycemic pharmaceutical composition, the specific steps are:

[0026] Step 1: Take repaglinide 5g, metformin hydrochloride 20g, pioglitazone 5g, sorbitol 15g, micronized silica gel 0.5g, polacrilin potassium resin (IRP88) 4g, stevioside 0.2g and ethanol 8g in a pharmaceutical grade clean area ;

[0027] Step 2: Weigh metformin and water and mix it at a mass ratio of 1:30 to make it completely dissolved, then add polacrilin potassium (IRP88) resin for ion exchange, react for 1 hour, filter and wash with water, and dry at 60°C , to prepare drug-containing resin powder, which is passed through an 80-mesh sieve for subsequent use;

[0028] Step 3: uniformly mix the drug-containing resin powder with repaglinide, pioglitazone, sorbitol, micronized silica gel, stevioside, and ethanol, and press into tablets with a specification of 0.25 g / tablet.

Embodiment 3

[0030] A preparation of a hypoglycemic pharmaceutical composition, the specific steps are:

[0031] Step 1: Take repaglinide 8g, metformin hydrochloride 18g, pioglitazone 8g, sorbitol 12g, micronized silica gel 0.3g, polacrilin potassium resin (IRP88) 3g, stevioside 0.5g and ethanol 8g in a pharmaceutical-grade clean area ;

[0032] Step 2: Weigh metformin and water and mix it at a mass ratio of 1:30 to make it completely dissolved, then add polacrilin potassium (IRP88) resin for ion exchange, react for 1 hour, filter and wash with water, and dry at 60°C , to prepare drug-containing resin powder, which is passed through an 80-mesh sieve for subsequent use;

[0033] Step 3: uniformly mix the drug-containing resin powder with repaglinide, pioglitazone, sorbitol, micronized silica gel, stevioside, and ethanol, and press into tablets with a specification of 0.25 g / tablet.

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Abstract

The invention belongs to the technical field of medicines, and in particular discloses a hypolycemic pharmaceutical composition and a preparation method thereof. The hypolycemic pharmaceutical composition consists of the following raw materials in parts by weight: 5-10 parts of repaglinide, 15-20 parts of metformin hydrochloride, 5-10 parts of pioglitazone, 10-15 parts of sorbitol, 0.1-0.5 part ofsuperfine silica powder, 1-5 parts of polacrilin potassium resin (IRP88), 0.1-0.5 part of stevioside and 5-10 parts of ethanol. According to the hypolycemic pharmaceutical composition provided by theinvention, various hypolycemic medicines, which are different in action, are combined, and on the basis of a synergistic effect between the hypolycemic medicines which complement each other's advantages, a curative effect is enhanced, blood glucose is effectively controlled and complications are reduced; and the hypolycemic pharmaceutical composition, when used for reducing the blood glucose, canalso effectively reduce body weight, lower blood lipids and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a drug composition for lowering blood sugar and a preparation method thereof. Background technique [0002] Diabetes mellitus (Diabetes Inellitus) is a metabolic disease of multiple etiologies, characterized by chronic hyperglycemia, accompanied by disorders of sugar, fat and protein metabolism caused by defects in insulin secretion and / or action. Diabetes can occur at any age. As the course of the disease prolongs, it is easy to cause histopathological damage such as systemic nerve, microvascular and macrovascular lesions, and can lead to chronic and progressive lesions of the heart, brain, kidney, nerves and eyes and other tissues and organs, resulting in Blindness, lower extremity gangrene, uremia, stroke or myocardial infarction will eventually occur, and even life-threatening. With the improvement of living standards, diabetes has become a common disease, and i...

Claims

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Application Information

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IPC IPC(8): A61K31/451A61K31/155A61K31/4439A61K9/20A61P3/10
CPCA61K31/451A61K9/2018A61K31/155A61K31/4439A61K2300/00
Inventor 罗昌兴
Owner 罗昌兴
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