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A method of manufacturing intravenous immunoglobulin from fraction iii

A solution, resulting technique, used in immunoglobulins, peptide/protein components, chemical instruments and methods, etc.

Inactive Publication Date: 2018-04-17
K 黄
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a certain percentage of IgG may precipitate out of the Fraction III paste, which includes 34 existing and newly discovered proteins

Method used

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  • A method of manufacturing intravenous immunoglobulin from fraction iii
  • A method of manufacturing intravenous immunoglobulin from fraction iii
  • A method of manufacturing intravenous immunoglobulin from fraction iii

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[0050] According to one embodiment of the present subject matter,…

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[0052] An implementation…

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Abstract

The present subject matter is directed to a method of manufacturing purified IVIG from Fraction III of plasma, comprising re-constituting a Fraction III paste in a buffer; adjusting the pH and temperature; adding ethanol and then gradually lowering the temperature; centrifuging and filtering the supernatant; ultra-filtrating to remove alcohol; undergoing weak anion exchange chromatography; ultra-filtrating to reach a desired protein concentration; aseptic filtrating; nano filtrating for virus removal; and incubating at low pH for virus inactivation to obtain a resulting Fraction III suspensioncomprising purified IVIG. The present subject matter is directed to IVIG having 14 newly-found proteins, namely KH 26, KH 27, KH 28, KH 29, KH 30, KH 31, KH 32, KH 33, KH 39, KH 40, KH 41, KH 42, KH43, and KH 44 for both liquid and lyophilized form.

Description

technical field [0001] This patent application claims priority to US Provisional Patent Application No. 62 / 142,212, filed April 2, 2015, filed by the present inventors and incorporated herein by reference in its entirety. [0002] This subject relates to intravenous immunoglobulin (IVIG) produced from plasma fraction III and its use, in particular for the treatment and prophylaxis of hepatitis C virus. Specifically, the present subject concerns a protein consisting of 14 newly discovered proteins, namely KH26, KH 27, KH 28, KH 29, KH 30, KH 31, KH 32, KH 33, KH 39, KH 40, KH 41, KH 42. Component III of KH 43 and KH 44 Process for the manufacture of IVIG for liquid and lyophilized forms. Background technique [0003] Immunoglobulin G (IgG) is an antibody and is a protein complex composed of four peptide chains, two identical heavy chains and two identical light chains, arranged in a typical antibody monomer The Y shape. Each IgG has two antigen binding sites. IgG, which r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K38/17A61K38/38
CPCA61K39/39525C07K16/00C07K2317/21C07K2317/73C07K16/065C07K2317/51C07K2317/515
Inventor K·黄
Owner K 黄
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