Preparation method and application of sodium azulene sulfonate and cetylpyridinium chloride compound mouthwash

A technology of cetylpyridinium chloride and sodium azulene, which is applied in skin care preparations, medical preparations containing active ingredients, oral care, etc., can solve problems such as user discomfort, wound or wound irritation, and achieve prevention and treatment. Mouth ulcers, good anti-inflammatory and antibacterial effects and therapeutic effects

Inactive Publication Date: 2018-04-24
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main components of mouthwashes on the market are essence, surfactant, fluoride, alcohol and water, etc. Some mouthwashes contain alcohol and other stimulating ingredients, which can cause severe irritation to the wound or wound surface, thus causing discomfort to the user

Method used

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  • Preparation method and application of sodium azulene sulfonate and cetylpyridinium chloride compound mouthwash
  • Preparation method and application of sodium azulene sulfonate and cetylpyridinium chloride compound mouthwash
  • Preparation method and application of sodium azulene sulfonate and cetylpyridinium chloride compound mouthwash

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: antibacterial experiment

[0014] Experimental strains: Escherichia coli, Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, Candida albicans, Streptococcus mutans, Actinobacillus actinomycetes.

[0015] Strain medium: LB plate, CDC anaerobic blood plate, common blood plate and nutrient broth medium.

[0016] Experimental group preparation: take 0.1g sodium azulene xanthate and dissolve it in 100ml sodium azulene xanthate gargle blank (the blank of azulene xanthate gargle is Blank: non-crystalline sorbitol, sodium benzoate, RH40 hydrogenated castor oil, propylene glycol , spearmint essence, ethanol, purified water), and prepare 0.1% sodium azulexanthate solution, and obtain 0.01% sodium azulexanthate, 0.02% sodium azulexanthate, and 0.03% sodium azulexanthate by dilution, so Our sodium azulene xanthate experimental group is 0.01% sodium azulexanthate, 0.02% sodium azulene xanthate, 0.03 sodium azulene xanthate, Blank; weigh 0.2g cet...

Embodiment 2

[0035] A kind of anti-inflammatory antibacterial mouthwash, the raw material that makes described mouthwash is: 0.05% cetylpyridinium chloride (CPC) (broad-spectrum sterilization)

Embodiment 3

[0037] A kind of anti-inflammatory antibacterial mouthwash, the raw material that makes described mouthwash is: 0.2% chlorhexidine (CHX)

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PUM

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Abstract

The invention discloses a preparation method and application of sodium azulene sulfonate and cetylpyridinium chloride compound mouthwash and belongs to the technical field of oral cleaning and care products. The mouthwash is prepared from 0.03% of sodium azulene sulfonate (SAS), 0.05% of cetylpyridinium chloride (CPC) and the balance water. Mouthwash plays an important role in oral medicine; however, the safety performance and wound surface repairing ability of the mouthwash affect the clinical effect of the mouthwash. The anti-inflammatory and antibacterial mouthwash provided in the inventionhas an obvious repair effect on oral ulcer and is safe and capable of fast repairing the wound surface of the oral ulcer.

Description

technical field [0001] The invention belongs to the technical field of oral cleaning care products, and is an anti-inflammatory and antibacterial compound mouthwash. Background technique [0002] Oral ulcer, also known as recurrent aphthous ulcer, is a disease with the highest incidence rate among oral mucosal diseases. Or lack of trace elements. Moreover, various bacteria such as Streptococcus mutans and Escherichia coli are also closely related to oral ulcers. [0003] Mouthwash, also known as oral wash, is an indispensable oral hygiene product in people's daily life. Its basic function is to clean teeth, freshen breath, and keep oral cavity clean. At present, the main components of mouthwashes on the market are essence, surfactant, fluoride, alcohol and water, etc., because some mouthwashes contain stimulating ingredients such as alcohol, which can cause severe irritation to the wound or wound surface, thereby causing discomfort to the user. Therefore, it is necessary ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/46A61Q11/00A61Q17/00A61K31/4425A61P1/02A61P31/02A61P31/04A61P31/10A61P29/00A61K31/185
CPCA61K8/466A61K8/4926A61K31/185A61K31/4425A61Q11/00A61Q17/005A61K2300/00
Inventor 龚爱华程洁唐宇韩秀陈曦曾建刘菲许婧
Owner JIANGSU UNIV
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