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Preparation method of thermosensitive liposome with whitening effect

A liposome and whitening technology, which is applied in the direction of medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve problems such as complicated use, and achieve improved stability, good whitening effect, and good stability Effect

Active Publication Date: 2018-05-08
苏州纳康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, for cosmetics that are directly applied on the surface of the human body, the current temperature-sensitive temperature of the existing temperature-sensitive liposomes is too high, and external heating equipment is used to help the release of the internal loads of the temperature-sensitive liposomes. For cosmetics that are used daily, too complicated to use

Method used

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  • Preparation method of thermosensitive liposome with whitening effect
  • Preparation method of thermosensitive liposome with whitening effect
  • Preparation method of thermosensitive liposome with whitening effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for preparing a thermosensitive liposome with whitening effect, characterized in that: the following steps are adopted:

[0031] A. Weigh β-acetylglycine alanine, ethyl linoleate, and cysteine ​​according to the mass ratio of 1:0.5:0.2 to prepare a whitening composition; according to the mass ratio of 1:2:0.5:6:40: 35. Weigh whitening composition, lipid, membrane stabilizer, ethanol, glycerin, deionized water; described lipid is hydrogenated lyso-lecithin, dipalmitoyl phosphatidylcholine, dimyristoyl lecithin by mass ratio The mixture of 1:2:1; The film stabilizer is the mixture of 2:1 by mass ratio in polysorbate-80, PEG-4 polyglycerol-2 stearate; The β-acetyl group used in the present embodiment Glycine-alanine was purchased from CORUM Company, and the product name was GenoWhite; the hydrogenated lysolecithin used in this example was purchased from Japan Nikko Co., Ltd., and the product name was NIKKOLLecinol LL-20;

[0032] B. Add lipid and membrane stabili...

Embodiment 2

[0036] A method for preparing a thermosensitive liposome with whitening effect, characterized in that: the following steps are adopted:

[0037] A. Weigh β-acetylglycine alanine, ethyl linoleate and cysteine ​​according to the mass ratio of 1:2:0.1 to prepare a whitening composition; according to the mass ratio of 1:3:0.3:6:20: 70 Weigh whitening composition, lipid, membrane stabilizer, ethanol, glycerol, deionized water; described lipid is hydrogenated lysolecithin, dipalmitoylphosphatidylcholine, dimyristoyl lecithin by mass ratio The mixture of 1:2:1; The film stabilizer is the mixture of 2:1 by mass ratio in polysorbate-80, PEG-4 polyglycerol-2 stearate; The β-acetyl group used in the present embodiment Glycine-alanine was purchased from CORUM Company, and the product name was GenoWhite; the hydrogenated lysolecithin used in this example was purchased from Japan Nikko Co., Ltd., and the product name was NIKKOL Lecinol LL-20;

[0038] B. Add lipid and membrane stabilizer t...

Embodiment 3

[0043] A method for preparing a thermosensitive liposome with whitening effect, characterized in that: the following steps are adopted:

[0044] A. Weigh β-acetylglycine-alanine, ethyl linoleate, and cysteine ​​according to the mass ratio of 1:1:1.5 to prepare a whitening composition; according to the mass ratio of 1:6:1:9:35: 50 take whitening composition, lipid, membrane stabilizer, ethanol, glycerol, deionized water; described lipid is hydrogenated lyso-lecithin, dipalmitoyl phosphatidylcholine, dimyristoyl lecithin by mass ratio The mixture of 1:2:1; The film stabilizer is the mixture of 2:1 by mass ratio in polysorbate-80, PEG-4 polyglycerol-2 stearate; The β-acetyl group used in the present embodiment Glycine-alanine was purchased from CORUM Company, and the product name was GenoWhite; the hydrogenated lysolecithin used in this example was purchased from Japan Nikko Co., Ltd., and the product name was NIKKOL Lecinol LL-20;

[0045] B. Add lipid and membrane stabilizer t...

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Abstract

The invention relates to a preparation method of thermosensitive liposome with a whitening effect. The preparation method is characterized by comprising the following steps: A, weighing a whitening composition, liposome, a membrane stabilizer, ethyl alcohol, glycerol and deionized water; B, adding the liposome and the membrane stabilizer into the ethyl alcohol, stirring under the condition that the temperature is 20 to 25 DEG C and the rotating speed is 300 to 800 rpm till a mixture is completely dissolved; adding the glycerol and continuously stirring till the liquid becomes clear and transparent to obtain a lipid membrane mixed solution; C, adding the whitening composition into the lipid membrane mixed solution and stirring under the condition that the temperature is 20 to 25 DEG C and the rotating speed is 300 to 800 rpm till the liquid becomes clear and transparent to obtain a whitening agent and lipid membrane pre-mixed solution; D, adding the whitening agent and lipid membrane pre-mixed solution into the deionized water, stirring for 10 minutes under the condition that the temperature is 20 to 25 DEG C and the rotating speed is 300 to 800 rpm, putting into a refrigerator andreducing the temperature to 2 to 5 DEG C; then at the pressure of 1500 bar, homogenizing for 1 to 3 times by using a high pressure homogenizer, thus obtaining the thermosensitive liposome with the whitening effect. The thermosensitive liposome with the whitening effect, disclosed by the invention, has the beneficial effects of simultaneous loading of three whitening active substances, good whitening effect and thermosensitive characteristic after transdermal absorption.

Description

technical field [0001] The invention relates to the technical field of preparation of temperature-sensitive liposomes in cosmetic carrier preparation technology, and more particularly relates to a preparation method of temperature-sensitive liposomes with whitening effect. Background technique [0002] With the acceleration of the pace of society and the intensification of environmental pollution, modern women's demands for whitening and freckle removal have further increased. Compared with European and American women, Asian women have even more pursuit of whitening and brightening skin due to the inherent differences in skin color. [0003] In the prior art, β-acetylglycine-alanine can reduce the transport of produced melanin to keratinocytes. Ethyl linoleate can reduce the activity of melanocytes and remove spots. Cysteine ​​can reduce the amount of melanin synthesis at the bottom of the skin, fundamentally achieve whitening effect. However, as a polypeptide substance, β...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/55A61K8/49A61K8/44A61K8/14A61K8/37A61Q19/02
CPCA61K8/14A61K8/37A61K8/447A61K8/4993A61K8/553A61K8/64A61K2800/56A61Q19/02
Inventor 徐静马超龙董颖
Owner 苏州纳康生物科技有限公司
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