Organ chip unit containing pipeline networks

Abstract

Disclosed is an organ chip unit containing pipeline networks. The unit comprises one or more chips containing input pipeline networks, one or more chips containing output pipeline networks, one or more chamber chips, at least two microporous membranes, at least two barrier cells and two encapsulation plates; the input pipeline networks are used for inputting, diverting and diffusing substances; the output pipeline networks are used for diffusing, converging and outputting the substances; the chamber chips contain parenchymal organ tissue; the parenchymal organ tissue is separated from the input and output pipeline networks by the microporous membranes; the barrier cells are located in the input and output pipeline networks and adhere to the microporous membranes; the two encapsulation plates are used for achieving encapsulation. By using the organ chip unit, the process can be simulated that the substances are diverted through various pipeline networks such as vascular/lymphatic/bronchial/glandular secretion networks, then enter the tissue and are subjected to metabolism in the tissue and gradually converged, the advantages of low cost and rapid performance of the chip are ensured,and meanwhile the organ chip unit is more accurate when applied to medicine screening, case studies and physiological analysis.

Description

technical field [0001] The invention relates to a human or animal bionic system, in particular to an organ chip unit containing a pipeline network. Background technique [0002] The construction of bionic tissue / organ / system models in vitro through microfluidic chips has the advantages of low consumption and fast response, which can not only make up for the inaccurate animal experiments and the high cost of clinical experiments, but also make up for the slow response of animal / human experiments. The disadvantage of long cycle, so it has been widely used. [0003] However, the current organ-on-a-chip is a simple accumulation of cells, and does not have the in vivo process of material transfer pipeline shunt-diffusion metabolism-pipe collection, that is, the current organ-on-a-chip does not have pipeline networks such as arteries, veins, and lymphatic vessels. There are inaccuracies in bionic analysis. Contents of the invention [0004] The main purpose of the present inve...

AI Technical Summary

Problems solved by technology

[0003] However, the current organ-on-a-chip is a simple accumulation of cells, and does not have the in vivo process of material transfer pipeline shunt-diffusion metabolism-p

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