Medical use of ginkgolide composition

A technology of ginkgolide and composition, applied in the field of application of ginkgolide composition in the treatment of multiple sclerosis, can solve the problem of not many, not many multiple sclerosis, no ginkgolide K composition and other problems, to achieve the effect of improving inflammatory response, good effect, and increased expression

Active Publication Date: 2020-06-16
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are not many reports on the use of simple ginkgolides for the treatment of multiple sclerosis, especially there are not many pharmacological studies on ginkgolide K, and there are no related reports on the composition of ginkgolide K.

Method used

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  • Medical use of ginkgolide composition
  • Medical use of ginkgolide composition
  • Medical use of ginkgolide composition

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Embodiment Construction

[0017] Hereinafter, the present invention will be described in more detail through specific embodiments, so as to better understand the solutions of the present invention and the advantages of various aspects thereof. However, the content of the specific embodiments described below is only for the purpose of illustration, rather than limiting the present invention.

[0018] It should be noted that if the specific conditions are not specified, they are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The raw materials or excipients used, as well as the reagents or instruments used without indicating the manufacturer, can be obtained from the market. conventional products. All percentages, ratios, proportions or parts are by weight unless otherwise indicated.

[0019] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. In addit...

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Abstract

The invention provides applications of a bilobalide composition in preparing medicines for treating multiple sclerosis. According to an established EAE animal model, after medicine intervention is given to the bilobalide composition, the result shows that the neurological score of an EAE animal is obviously lowered, the falling latency time is obviously prolonged, which proves that the bilobalidecomposition can obviously reduce the attack degree of EAE, meanwhile, the expression of IL-17 and IFN-gamma in the serum of the EAE mouse is obviously reduced, the expression of IL-4 is obviously increased, and therefore, the bilobalide composition can improve the inflammatory reaction caused by imbalance of the contents of the cell factors.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of ginkgolide composition in treating multiple sclerosis. Background technique [0002] Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system. the main reason. MS is divided into six major clinical syndromes: clinically isolated syndromes (CIS), remitting-relapsing MS, secondary progressive MS, progressive-relapsing MS, primary progressive MS, and acute MS. In recent years, the incidence rate has shown a continuous upward trend. The number of female patients is twice that of males. The number of patients in northern my country is more than that in the south. brought huge socio-economic impacts. [0003] Experimental autoimmune encephalomyelitis (experimental autoimmune encephalomyelitis, EAE) is internationally recognized as an ideal animal model of MS. Protein immune construction, the central nervous system (central nervo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P25/28A61P37/02
CPCA61K31/365
Inventor 萧伟李贵平王振中刘秋许治良周军周建明胡晗绯
Owner JIANGSU KANION PHARMA CO LTD
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