A kind of cream preparation containing aclomethasone dipropionate
A technology of aclomethasone dipropionate and cream, which is applied in the direction of medical preparations containing active ingredients, medical preparations without active ingredients, anti-inflammatory agents, etc., which can solve irritating odor, aggravated storage conditions, and unfavorable production operations and other problems, to achieve the effect of good buffering capacity, sustained sustained drug release, and strong emulsifying capacity
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Embodiment 1 2
[0080] The stability of embodiment 1 aclomethasone dipropionate in different states
[0081] The result is as follows:
[0082] Table 1 The stability research results of aclomethasone dipropionate in solution state and solid state
[0083]
[0084]
[0085] Test Conclusions:
[0086] The present invention finds that the stability of aclomethasone dipropionate is related to its existing state, and the stability of aclomethasone dipropionate in solid state is significantly better than that in solution state.
Embodiment 2 2
[0087] Embodiment 2 Alclomethasone dipropionate dispersion medium screening
[0088] The result is as follows:
[0089] The dispersion situation of table 2 aclomethasone dipropionate in different media
[0090]
[0091] Test Conclusions:
[0092] Different excipients have certain dispersibility to aclomethasone dipropionate.
[0093] Cetostearyl alcohol has the best wetting and dispersing ability to aclomethasone dipropionate.
Embodiment 3 2
[0094] Embodiment 3 Alclomethasone dipropionate dispersion condition screening
[0095] The result is as follows:
[0096] Dispersion of the main drug under different dispersion conditions in table 3
[0097]
[0098]
[0099] Test Conclusions:
[0100] Cetostearyl alcohol is used as the dispersion medium, the dispersion temperature is 70-80°C, and the dispersion time is 5 minutes. Alclomethasone dipropionate can be uniformly dispersed.
[0101] Prolonging the dispersion time to 60min, the crystal size did not change significantly.
[0102] Cetostearyl alcohol is used as the dispersion medium of aclomethasone dipropionate, the optional dispersion temperature range is wide, the dispersion time range is wide, and the operability is strong.
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