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Two-dimensional Magnetic Resonance Single-Voxel Localized J-Decomposition Spectroscopy Method for Realizing Pure Absorption Lineshape

A spectral method and magnetic resonance technology, applied in the field of obtaining two-dimensional localized J-decomposition spectrum, can solve the problems of reducing signal resolution and influence, and achieve good resolution effect

Inactive Publication Date: 2020-04-21
XIAMEN UNIV
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Problems solved by technology

The two-dimensional localized spectrum can realize the separation of signals. Compared with the one-dimensional spectrum, it is easier to distinguish various signals, but its signal is affected by phase distortion.
Phase distortion will cause the signal to discard the phase information and display in amplitude mode, which reduces the resolution of the signal

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  • Two-dimensional Magnetic Resonance Single-Voxel Localized J-Decomposition Spectroscopy Method for Realizing Pure Absorption Lineshape
  • Two-dimensional Magnetic Resonance Single-Voxel Localized J-Decomposition Spectroscopy Method for Realizing Pure Absorption Lineshape
  • Two-dimensional Magnetic Resonance Single-Voxel Localized J-Decomposition Spectroscopy Method for Realizing Pure Absorption Lineshape

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Embodiment Construction

[0027] Below in conjunction with accompanying drawing and implementation example, the present invention will be further described:

[0028] A method for obtaining a pure absorption linear single voxel two-dimensional localized nuclear magnetic resonance J-decomposition spectrum, the main steps of which are:

[0029] 1) collecting the nuclear magnetic resonance image of the sample, and determining the localized area;

[0030] 2) collecting a one-dimensional localization spectrum of the localization area;

[0031] 3) Determine the spectrum range of the solution sample signal;

[0032] 4) take the central frequency of the spectrum range of the solution sample signal as the excitation center of the soft pulse, determine the soft pulse width according to the spectrum peak interval of the signal, and measure the power of the 180° soft pulse of the sample;

[0033] 5) The ZS module is composed of layer selection gradient, soft pulse and symmetrical phase dispersion gradient. To det...

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Abstract

The invention provides a method for realizing a pure absorption line type two-dimensional magnetic resonance single-voxel localized J decomposition spectrum. ZS modules are added at different positions to form an N sequence and an R sequence, the experimental result of the R sequence symmetrically flipped along an indirect dimension F1 = 0 Hz, and superimposing the symmetrically flipped experimental result of the R sequence and the result of the N sequence to obtain the pure absorption line type single-voxel two-dimensional localized J decomposition spectrum. The N sequence is formed through adding the ZS module after the first 90 DEG localized pulse, the R sequence is formed through adding the ZS module after the last 180 DEG localized pulse, the delay times at both sides of the last 180DEG of each of the sequences are uniform and are t1 / 2, and indirect dimensional F1 evolution is performed. The ZS module consists of a selective 180 DEG soft pulse, a Z-directional gradient magnetic field and a symmetric spoiled gradient, so the selective 180 DEG soft pulse realizes the evolution refocusing of different nuclei at different spatial positions, and the coherence order of the resonance nuclei transfers; and the ZS modules of the N sequence and the R sequence have different positions, so final two-dimensional signal composition modes are different.

Description

technical field [0001] The invention relates to obtaining two-dimensional localized J-decomposition spectrum on a magnetic resonance instrument, in particular to a single-pixel two-dimensional localized J-decomposition spectrum method capable of sampling on a magnetic resonance instrument to realize a pure absorption line. Background technique [0002] Localized nuclear magnetic resonance spectroscopy (MRS), as a supplementary tool to magnetic resonance imaging (MRI), has important applications in the study of living tissues. MRS can selectively and non-invasively measure the chemical composition and structure in the tissue, the change of the chemical environment and the existing form of molecules in the living body. This information is a bridge between biochemical changes and disease pathology, which is beyond the reach of any previous imaging technology. acquired. Point-resolved spectroscopy (Bottomley PA. Spatial Localization in NMR Spectroscopy in Vivo. Annals of the Ne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 林雁勤田丹段博陈忠
Owner XIAMEN UNIV
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