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Telomeres capable of selectively prolonging adult stem cells in individuals

An adult stem cell, selective technology, applied in the field of stem cells, to achieve the effect of low cost and simple operation

Inactive Publication Date: 2018-06-22
黄必录
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Young neurons express amyloid-beta-degrading enzymes to prevent amyloid-beta build-up in neurons, but older people's genes for amyloid-beta-degrading enzymes are gradually switched off, resulting in beta-amyloid A large amount of amyloid accumulates in neurons, which is the cause of Alzheimer's disease, and it is also the reason why major pharmaceutical companies have repeatedly failed to treat Alzheimer's with drugs that clear beta-amyloid

Method used

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Experimental program
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Embodiment Construction

[0019] The present invention is described in further detail below.

[0020] Selectively lengthening telomeres of adult stem cells in an individual characterized by steps comprising:

[0021] 1. Mix the RNA transfection reagent in the animal body with hTERTmRNA to form a transfection complex;

[0022] 2. Dilute the transfection complex with 10% glucose solution and make up with pure water to obtain a final glucose concentration of 5%;

[0023] 3. The prepared transfection complex with a final glucose concentration of 5% is intravenously injected into the human body. It should be prepared and used immediately, and should not be stored for a long time.

[0024] 4. The hTERT mRNA is chemically modified, which can avoid the body's immune response, is not easy to be degraded by ribozymes, and can stably produce hTERT.

[0025] Human telomerase is composed of three parts: telomerase catalytic subunit (hTERT), telomerase-related protein 1 (TP1), and telomerase RNA component (hTR). ...

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Abstract

The invention belongs to the field of stem cells, and in particular relates to telomeres capable of selectively prolonging adult stem cells in individuals. Individual aging is caused by shortening ofthe telomeres of the multipotent adult stem cells, therefore, only if the telomeres of the multipotent adult stem cells are enabled to extend to the level of young people, the function of the aging tissues and organs in the individuals can be inverted to the level of the young people. For the telomeres, an RNA transfection reagent in the body of an animal is mixed with hTERTmRNA, and the mixture enters the human body through intravenous injection, so that the telomeres of the various adult stem cells in the individuals are prolonged.

Description

technical field [0001] The present invention is in the field of stem cells and in particular relates to selectively lengthening the telomeres of adult stem cells in an individual. Background technique [0002] Cells in individual tissues can be divided into two categories: "adult stem cells" and "functional cells". Adult stem cells are a type of stem cells that can self-renew and differentiate into functional cells in tissues, such as hematopoietic stem cells, mesenchymal cells, and neural cells. Stem cells, cardiac stem cells, etc. (hepatocytes are special, having two attributes of adult stem cells and functional cells). Both functional cells and adult stem cells die due to various reasons, but both can be filled by adult stem cells through cell differentiation and self-replication. Therefore, cell death is not the cause of individual aging. [0003] In 1998, I published an article in Yenching Medical Newsletter (Reference: Huang Bilu, Mechanism, Significance and Treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61P39/06A61P35/00A61P31/18
CPCA61K48/005
Inventor 黄必录
Owner 黄必录