Preparation method of Albendazole liposome preparation
A technology of albendazole lipid and albendazole, which is applied in the field of preparation of albendazole liposome preparations, can solve problems such as limiting the absorption of albendazole, achieve reduction of toxic and side effects, long retention time, The effect of simple preparation method
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[0017] Example 1
[0018] A preparation method of albendazole liposome preparation includes the following steps:
[0019] (1) Preparation of ether solution: Weigh 10 to 90 parts of soybean lecithin and 5 to 40 parts of cholesterol in parts by weight and dissolve in 50 to 120 parts of anhydrous ether, and stir to dissolve at a temperature of 50 to 65°C Obtain the ether solution completely, ready for use;
[0020] (2) Preparation of albendazole solution: Weigh 1-2 parts of albendazole and dissolve it in a phosphate buffer solution with a concentration of 100-200mmol / L, and place it at a temperature of 60-70℃, stir and dissolve to obtain albendazole. Dazole solution, heat preservation, standby; the mass ratio of the albendazole to 100-200mmol / L phosphate buffer solution is 1; (10-100);
[0021] (3) Mix the albendazole solution obtained in step (2) with the ether solution obtained in step (1), shake, sonicate for 5-10 minutes, distill under reduced pressure to remove organic solvents, an...
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[0022] Example 2
[0023] A preparation method of albendazole liposome preparation includes the following steps:
[0024] (1) Preparation of ether solution: weigh out 75 parts of soybean lecithin and 25 parts of cholesterol in 80 parts of anhydrous ether in parts by weight, and place them at a temperature of 50~65°C and stir to dissolve to obtain the ether solution. ;
[0025] (2) Preparation of albendazole solution: Weigh 1 part of albendazole and dissolve it in a phosphate buffer solution with a concentration of 100mmol / L, place it at a temperature of 65°C and stir to dissolve to obtain the albendazole solution, keep it warm, Standby; the mass ratio of the albendazole to 100mmol / L phosphate buffer solution is 1; 50;
[0026] (3) Mix the albendazole solution obtained in step (2) with the ether solution obtained in step (1), shake, sonicate for 10 minutes, distill under reduced pressure to remove organic solvents, and then stir and hydrate in a 65°C water bath for 15 minutes Finally...
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[0027] Example 3
[0028] A preparation method of albendazole liposome preparation includes the following steps:
[0029] (1) Preparation of ether solution: Weigh 80 parts of soybean lecithin and 30 parts of cholesterol in 110 parts of anhydrous ether in parts by weight, and place them at a temperature of 60°C and stir to dissolve to obtain the ether solution for use;
[0030] (2) Preparation of albendazole solution: Weigh 1.5 parts of albendazole and dissolve it in a phosphate buffer solution with a concentration of 150mmol / L, place it at a temperature of 65°C and stir to dissolve to obtain the albendazole solution, keep warm, Standby; the mass ratio of the albendazole to 150mmol / L phosphate buffer solution is 1; 80;
[0031] (3) Mix the albendazole solution obtained in step (2) with the ether solution obtained in step (1), shake, sonicate for 8 minutes, distill under reduced pressure to remove organic solvents, and then stir and hydrate in a 65°C water bath for 10 minutes Finally, ...
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