Synthesis method of resveratrol

A technology for resveratrol and a synthesis method, which is applied in chemical instruments and methods, preparation of amino compounds, preparation of organic compounds, etc., can solve the problems of long steps, high industrial waste and high production risk, and achieves short steps and high yields. High rate and low price effect

Active Publication Date: 2018-07-06
上海巧坤化工科技有限公司
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The reported synthesis method of resveratrol is mainly based on 3,5-dihydroxybenzoic acid as raw material, through dimethyl sulfate methylation, sodium borohydride-boron trifluoride reduction, solid phosgene chlorination, Esterification of triethyl phosphate, Wittig coupling, demethylation and other reactions, the existing process has problems such as high raw material cost, long steps, high production risk and high industrial waste

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthesis method of resveratrol
  • Synthesis method of resveratrol
  • Synthesis method of resveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] This example discloses a synthetic method of resveratrol, the method comprising the preparation process of 3,5-dibromo-4-aminotoluene, the preparation process of 3,5-dibromotoluene, (E)-1, The preparation technology of 3-dibromo-5-(4-methoxystyrene) benzene, the preparation technology of (E)-1,3-dimethoxy-5-(4-methoxystyrene) benzene and The preparation technology of resveratrol; Synthetic route is:

[0055]

[0056] Include the following steps:

[0057] 1. The reaction route of step 1 is:

[0058]

[0059]The specific method is as follows: 214 grams of p-toluidine are dissolved in 500 mL of methanol and 500 mL of water, cooled to 0 ° C in an ice bath, and then 490 grams of 20% dilute sulfuric acid solution is added, the reaction solution becomes a brownish red suspension, and stirred 30 minutes; add 336g of liquid bromine dropwise to the reaction solution at 0-5°C, there is a significant temperature rise, the reaction solution turns purple, and the system is sl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a synthesis method of resveratrol. The synthesis method comprises the steps of a preparation technology of 3,5-dibromo-4-aminotoluene, a preparation technology of 3, 5-dibromotoluene, a preparation technology of (E)-1,3-dibromo-5-(4-methoxy-styrene)benzene, a preparation technology of (E)-1,3-dimethoxy-5-(4-methoxy-styrene)benzene and a preparation technology of resveratrol. The synthesis method has the advantages of being low in raw material price, less in step, high in yield and suitable for scale production.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a method for synthesizing resveratrol. Background technique [0002] Resveratrol is a polyphenol compound containing stilbene structure, also known as stilbenotriol, which is widely found in plants such as glucose, knotweed and peanut. It is a natural antioxidant and a chemopreventive agent for tumors. It has been hailed as another new green anticancer drug after paclitaxel. It is also a chemopreventive agent for reducing platelet aggregation, preventing and treating atherosclerosis, and cardiovascular and cerebrovascular diseases. It can be used as dietary supplement, food additive and health food, etc., and has a good industrialization market prospect. Because the content of resveratrol in plants is very low, and the extraction cost is high, and the purification process is very cumbersome, it is of great practical significance to use new high-efficiency and low-cost chemical ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/00C07C39/21
CPCC07C17/35C07C37/00C07C41/01C07C41/30C07C209/74C07C39/21C07C43/215C07C43/225C07C25/02C07C211/52
Inventor 左理王文华胡伟杰牟家鹏
Owner 上海巧坤化工科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap