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Dendritic molecule modified ferriferrous oxide magnetic nanomaterial and preparation method and application thereof

A technology of ferroferric oxide and magnetic nanometers, which is applied in the direction of magnetic materials, ferrous oxides, iron oxide/iron hydroxide, etc., to achieve stable structure, good dispersion, and reduce cytotoxicity

Active Publication Date: 2018-07-13
广东南芯医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, Fe 3 o 4 Nanoparticles are subject to many restrictions in the production and application process

Method used

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  • Dendritic molecule modified ferriferrous oxide magnetic nanomaterial and preparation method and application thereof
  • Dendritic molecule modified ferriferrous oxide magnetic nanomaterial and preparation method and application thereof
  • Dendritic molecule modified ferriferrous oxide magnetic nanomaterial and preparation method and application thereof

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preparation example Construction

[0032] A preparation method of a dendrimer-modified ferroferromagnetic nanometer material, comprising the following steps:

[0033] 1) Synthesis of Fe 3 o 4 Nano bare sphere: with FeCl 3 As raw material, Fe was prepared by hydrothermal method 3 o 4 Naked nanosphere;

[0034] 2) Synthesis of dendrimers: dissolving dendritic polyamide-amine and siloxane containing alkyne-terminated dendrimers in a solvent, adding an initiator, sealing the solution system for reaction, and the reaction product is precipitated, washed, and dried , to obtain a dendritic molecule whose terminal group is siloxane;

[0035] 3) Synthesis of ferroferric oxide magnetic nanomaterials modified by dendrimers: Fe 3 o 4 Nano bare spheres are ultrasonically dispersed in an alcohol-water mixture, the resulting dispersion is mixed with ammonia water, then mixed with dendrimers whose terminal groups are siloxane, and then washed with water under magnetic field attraction conditions to obtain The above-men...

Embodiment 1

[0063] Embodiment 1 (synthetic Fe 3 o 4 Nano bare sphere example 1):

[0064] Anhydrous FeCl 3 Dissolve in ethylene glycol, then add anhydrous sodium acetate and sodium citrate in turn, stir vigorously for 10 minutes, place in a muffle furnace, react for 10 hours at 150°C, and wash with ethanol for 3 times to obtain Fe 3 o 4 Nanoparticles.

[0065] Anhydrous FeCl in this embodiment 3 , anhydrous sodium acetate, and sodium citrate in a molar ratio of 1:0.1:1; the amount of ethylene glycol added is 10 mg of anhydrous FeCl per 1 mL 3 count.

Embodiment 2

[0066] Embodiment 2 (synthetic Fe 3 o 4 Nano bare sphere example 2):

[0067] Anhydrous FeCl 3 Dissolve in ethylene glycol, then add anhydrous sodium acetate and sodium citrate in turn, stir vigorously for 30 minutes, place in a muffle furnace, react for 16 hours at 250 ° C, wash with ethanol for 3 times, and obtain Fe 3 o 4 Nanoparticles.

[0068] Anhydrous FeCl in this embodiment 3 , anhydrous sodium acetate, and sodium citrate in a molar ratio of 1:0.5:5; the amount of ethylene glycol added is 30mg of anhydrous FeCl per 1mL 3 count.

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Abstract

The invention discloses a dendritic molecule modified ferriferrous oxide magnetic nanomaterial and a preparation method and an application thereof. The dendritic molecule modified ferriferrous oxide magnetic nanomaterial is a surface modified dendritic molecule Fe<3>O<4> nanomaterial. Meanwhile, the invention discloses a preparation method of the magnetic nanomaterial; the preparation method comprises the step of 1) performing synthesis of Fe<3>O<4> nanometer bare balls; 2) performing synthesis of dendritic molecules; and 3) performing synthesis of the dendritic molecule modified ferriferrousoxide magnetic nanomaterial. The invention also discloses an application of the magnetic nanomaterial. The dendritic molecule modified ferriferrous oxide magnetic nanomaterial disclosed in the invention is uniform in grain diameter, obvious in magnetic effect, high in biocompatibility; and more reaction sites for further functionalization are provided by a large amount of amino groups on the peppery of the material, so that the magnetic nanomaterial is expected to be widely applied to the field of biomedical engineering.

Description

technical field [0001] The invention relates to a ferroferric oxide magnetic nanometer material modified by dendrimers, a preparation method and an application thereof. Background technique [0002] Fe 3 o 4 Nanoparticles have many excellent properties. They can move directionally under an external magnetic field, and can generate heat under the action of an external alternating electromagnetic field. Their chemical properties are stable and they have a wide range of uses. However, Fe 3 o 4 Nanoparticles are subject to many restrictions in the process of production and application. First Fe 3 o 4 It is magnetic and easy to agglomerate; on the other hand, because nanoparticles have a high specific surface area and are in a high-energy state, they are unstable systems, so they have a strong tendency to aggregate; secondly, there are many unsaturated bonds on the surface atoms of nanoparticles, which are very easy to Combining with other atoms tends to be stable; again, ...

Claims

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Application Information

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IPC IPC(8): H01F1/00H01F41/00C01G49/08C08G73/02A61K47/02A61K47/34A61K49/12
CPCA61K47/02A61K47/34A61K49/124C01G49/08C01P2004/32C01P2004/62C08G73/028H01F1/0045H01F41/00
Inventor 陈涛马栋蔡祥张召
Owner 广东南芯医疗科技有限公司
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