A method for synthesizing tert-butoxy substituted styrene and derivatives thereof
A technology of tert-butoxy and derivatives, which is applied in the field of synthesizing tert-butoxy-substituted styrene and derivatives thereof, can solve the problems of high cost and high cost of synthesis methods, and achieves reduction of side reactions, good selectivity, and catalytic performance. Efficient effect
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Embodiment 1
[0059] This example involves synthesizing 3-tert-butoxychlorobenzene by using m-chlorophenol and isobutylene as raw materials, then preparing Grignard reagent from 3-tert-butoxychlorobenzene, and reacting with vinyl chloride to synthesize 3-tert-butoxystyrene . The reaction scheme of the present embodiment is as follows:
[0060]
[0061] 1. The first step: add 200g m-chlorophenol to toluene at 20±10℃, start stirring until the solid is dissolved, add 5.5g methanesulfonic acid, and then start to introduce isobutylene gas at 10-20℃, there is obvious Exothermic phenomenon, keep the internal temperature between 10-20 ℃ by ice-water cooling. After about 2-3 hours, the ventilation was completed, the reaction system was sealed, and the reaction was carried out at room temperature overnight. After 17 hours of reaction, samples were taken for analysis (in control 1, raw material < 20%), and post-processing was carried out after the intermediate control was qualified.
[0062] Add...
Embodiment 2
[0067] This embodiment involves the synthesis of 3-tert-butoxybromobenzene by using m-bromophenol and isobutylene as raw materials, then preparing Grignard reagent from 3-tert-butoxybromobenzene, and reacting with vinyl chloride to synthesize 3-tert-butoxystyrene . The reaction scheme of this example is similar to that of Example 1, except that m-bromophenol is used as a raw material instead of m-chlorophenol.
[0068] 1. The first step: add 270g m-bromophenol to toluene at 20±5℃, start stirring until the solid is dissolved, add 5.5g methanesulfonic acid, and then start to introduce isobutylene gas at 10-20℃, there is obvious Exothermic phenomenon, keep the internal temperature between 10-20 ℃ by ice-water cooling. After about 2-3 hours, the ventilation was completed, the reaction system was sealed, and the reaction was carried out at room temperature overnight. After 17 hours of reaction, samples were taken for analysis (in control 1, raw material < 20%), and post-processin...
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