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A method for increasing the magnetic heat generation rate of calcium phosphate magnetic bone cement

A technology of bone cement and calcium phosphate, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of increasing time cost and economic cost, complicated process engineering, high price, etc., and save time cost and economic cost, process Simple operation and short time-consuming effect

Active Publication Date: 2021-01-05
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve this problem, certain means can be used to make it functional when preparing ferric oxide, but this method is usually very expensive, and the output is small, so it is not suitable for the relatively large amount of use in magnetic bone cement; Another method is to use a certain process to functionalize the surface of ferroferric oxide after the synthesis of ferroferric oxide. This method is complex in process engineering, and in the later modification process, nitrogen protection is required to prevent oxidation and other special Process conditions, increased time cost and economic cost

Method used

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  • A method for increasing the magnetic heat generation rate of calcium phosphate magnetic bone cement
  • A method for increasing the magnetic heat generation rate of calcium phosphate magnetic bone cement
  • A method for increasing the magnetic heat generation rate of calcium phosphate magnetic bone cement

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preparation example Construction

[0039] 2. Preparation of Magnetic Bone Cement

[0040] (1) Prepare a citric acid solution with a concentration of 0.5 mol / L as the liquid phase of the bone cement for later use;

[0041] (2) Weigh β-tricalcium phosphate and Ca(H 2 PO 4 ) 2 ·H 2 O powder, β-tricalcium phosphate and Ca(H 2 PO 4 ) 2 ·H 2 O powder is 200 mesh sieves, puts into the mortar and grinds for 15min, makes solid-phase phosphate powder, for subsequent use;

[0042] (3) Take the modified Fe prepared in step 1 (5) according to the weight ratio of 4:6 3 o 4 Put the magnetic functional phase and the solid-phase phosphate powder prepared in step 2 (2) into a mortar, grind for 15 minutes, and mix evenly to obtain a bone cement solid-phase mixture, which is set aside;

[0043] (4) Add the citric acid solution in step 2 (1) to the solid phase mixture prepared in step 2 (3) according to the ratio of 1 mL of bone cement liquid phase for every 3 g of bone cement solid phase mixture, and mix with a stainle...

Embodiment 1

[0046] A method for improving the magnetic heat generation rate of calcium phosphate magnetic bone cement, comprising the following steps:

[0047] 1. Fe 3 o 4 Magnetic functional phase and modified Fe 3 o 4 Preparation of Magnetic Functional Phase

[0048] Fe 3 o 4 by FeSO 4 and FeCl 3 The deionized aqueous solution is prepared by high-temperature reaction after adjusting the pH of the solution with sodium hydroxide solution, in which FeSO 4 , FeCl 3 1. The ratio of deionized water is: 335mg: 490mg: 8mL; the concentration of the sodium hydroxide solution is 2mol / L.

[0049] (1) The weighed FeSO 4 , FeCl 3 Dissolve in deionized water, stir until completely dissolved, set aside;

[0050] (2) Adjust the pH of the solution to 6.5 with sodium hydroxide solution, stir for 30 min, and set aside;

[0051] (3) Put the suspension in step 1 (2) into a hydrothermal reaction kettle, 160°C, 6h;

[0052] (4) Separation of the precipitate obtained in step 1 (3), washing with de...

Embodiment 2

[0060] A method for improving the magnetic heat generation rate of calcium phosphate magnetic bone cement, comprising the following steps:

[0061] 1. Fe 3 o 4 Magnetic functional phase and modified Fe 3 o 4 Preparation of Magnetic Functional Phase

[0062] Fe 3 o 4 by FeSO 4 and FeCl 3 The deionized aqueous solution is prepared by high-temperature reaction after adjusting the pH of the solution with sodium hydroxide solution, in which FeSO 4 , FeCl 3 1. The ratio of deionized water is: 330mg: 492mg: 8mL; the concentration of the sodium hydroxide solution is 2mol / L.

[0063] (1) The weighed FeSO 4 , FeCl 3 Dissolve in deionized water, stir until completely dissolved, set aside;

[0064] (2) Adjust the pH of the solution to 6.5 with sodium hydroxide solution, stir for 30 min, and set aside;

[0065] (3) Put the suspension in step 1 (2) into a hydrothermal reaction kettle, 160°C, 6h;

[0066] (4) Separation of the precipitate obtained in step 1 (3), washing with de...

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Abstract

The invention provides a method for improving a magnetic heat generating rate of calcium phosphate magnetic bone cement. A hydrothermal method is utilized to synthesize a Fe3O4 magnetic functional phase, carbon powder is utilized to modify the synthesized Fe3O4 magnetic functional phase, and then the modified Fe3O4 magnetic functional phase is compounded with solid-phase phosphate powder to prepare the magnetic bone cement. According to the method disclosed by the invention, the carbon powder is utilized as a modifying agent, and ferroferric oxide and a bone cement matrix are separated; compared with a modified material without carbon powder being added, temperature rise of the material is quicker, time for achieving temperature rise balance is shorter, thermal therapy time is shortened, and a thermal tolerance effect caused by too long heating time is reduced.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for increasing the magnetic heat generation rate of calcium phosphate magnetic bone cement. Background technique [0002] Adding magnetic functional phases into bone cement to prepare magnetic bone cement materials is a hot spot in the design and development of biomaterials for postoperative adjuvant treatment of bone tumors. This is because magnetic bone cement is used as a bone graft material after bone tumor resection, on the one hand, it can play its bone defect repair function, and play a role in filling, repairing and strengthening bone tissue; on the other hand, the magnetic properties of magnetic bone cement It can absorb the energy of the alternating magnetic field under the alternating magnetic field and convert it into heat energy, heating the diseased tissue. Utilizing the characteristic that tumor cells are more sensitive to heat than normal ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/02A61L27/08A61L27/50A61L27/12
CPCA61L27/025A61L27/08A61L27/12A61L27/50A61L27/54A61L2300/102A61L2430/02
Inventor 赵三团李光大张开丽张鲲鹏陈卉卉理仁杰于耀智李景华鲍建峰梁高峰
Owner HENAN UNIV OF SCI & TECH
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