Macromolecule-based hydrogel composition and use thereof

A technology of hydrogel and composition, which is applied in the field of supramolecular-based hydrogel composition, can solve rare problems and achieve the effect of enhancing new bone formation

Active Publication Date: 2018-07-31
UNIV IND COOP GRP OF KYUNG HEE UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, examples of the application of hydrogels to living organisms are very rare

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  • Macromolecule-based hydrogel composition and use thereof
  • Macromolecule-based hydrogel composition and use thereof
  • Macromolecule-based hydrogel composition and use thereof

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[0031] Preparation method of supramolecular-based hydrogel composition

[0032]One aspect of the present invention provides a method for preparing a supramolecular-based hydrogel composition. A method for preparing a supramolecular-based hydrogel composition according to an example of the present invention includes the following steps: graft copolymerization in which a linear polymer is bonded to a biocompatible polymer as a main chain in a branched chain form The ring molecule and the bone formation promoting drug solution are added to the aqueous solution of the substance and reacted. In addition, the method for preparing a supramolecular-based hydrogel composition according to another example of the present invention includes the following steps: The ring molecule and the clathrate solution are added to the aqueous solution of the graft copolymer and reacted, wherein the clathrate solution is formed by cladding the bone formation-promoting drug into the host molecule. T...

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Abstract

The present invention provides a hydrogel composition containing a polyrotaxane or Pseudopolyrotaxane (PPRX)-structured macromolecular hydrogel; and a bone formation promoting drug. The polyrotaxane or Pseudopolyrotaxane-structured macromolecule-based hydrogel composition according to the present invention improves the water solubility of a bone formation promoting compound capsulated in the hydrogel, thereby sustainedly releasing the bone formation promoting compound for a long period of time. Especially, in the hydrogel composition containing a bone formation promoting compound capsulated inthe hydrogel in a form of an inclusion complex, the bone formation promoting compound is promptly released and the new bone formation is promoted. Therefore, the macromolecule-based hydrogel composition according to the present invention can be used as a biocompatible scaffold for bone tissue regeneration.

Description

technical field [0001] The present invention relates to a supramolecular-based hydrogel composition, etc., more specifically, to a supramolecular hydrogel having a polyrotaxane (polyrotaxane) or pseudopolyrotaxane (Pseudopolyrotaxane, PPRX) structure Compositions comprising forms of bone formation promoting compounds and their use for bone tissue regeneration. Background technique [0002] Bone loss due to bone disease and fractures is a common diagnosis in orthopedic, neurosurgery, plastic surgery or dentistry. Bone regeneration can be induced using traditional methods such as drugs or physical therapy, and in cases of extensive bone loss, surgery to remove the bone. Compared with other available methods, autografting (Autografting) is an ideal method for the treatment of bone loss. However, surgical treatment methods have several limitations due to the damage to the patient's tissue. In addition, allografting and xenografting, which are the other two types of transplant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/54A61L27/20
CPCA61L27/20A61L27/52A61L27/54
Inventor 李德远
Owner UNIV IND COOP GRP OF KYUNG HEE UNIV
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