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Oral spray for prevention and auxiliary treatment on periodontitis and preparation method of oral spray

An oral spray and adjuvant therapy technology, applied in the field of medicine, can solve the problems of poor pathogenic source effect, weak periodontitis prevention application, poor antibacterial and anti-inflammatory effects, etc., to achieve inhibition of pathogenic bacteria copolymerization and biological Membrane formation, inhibitory expression and osteoclast formation, anti-inflammatory and preventive effects on alveolar bone resorption

Active Publication Date: 2018-08-10
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of the invention can be used for oral care of critically ill patients, caries, periodontitis, and treatment of patients with long-term unhealed stomatitis. Weak preventive application, poor antibacterial and anti-inflammatory effects

Method used

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  • Oral spray for prevention and auxiliary treatment on periodontitis and preparation method of oral spray
  • Oral spray for prevention and auxiliary treatment on periodontitis and preparation method of oral spray
  • Oral spray for prevention and auxiliary treatment on periodontitis and preparation method of oral spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] An oral spray for preventing and assisting the treatment of periodontitis, comprising the following percentages of raw materials:

[0050]

[0051]

[0052] The sum of each component is 100%.

[0053] The above-mentioned preparation method of the oral spray for preventing and assisting the treatment of periodontitis comprises steps:

[0054] (1) Weighing 5g of epigallocatechin gallate, 1g of theaflavins, 1g of proanthocyanidin A1, 5g of xylitol, and 2g of citric acid were dissolved in 500g of sterile water, and mixed uniformly to obtain solution A;

[0055] (2) Weigh 1g licochalcone A, 1g rhododendron, 0.5g luteolin, 0.5g ferulic acid, 3g levomenthol, 1g notoginsenoside R1, 0.1g ginsenoside Rb1, 0.1g emodin Configure solution B with 50g of ethanol;

[0056] (3) Mix solution A and solution B evenly, add sterile water to 1000 g, filter and sterilize the obtained solution, and fill it in a spray bottle to obtain the product.

Embodiment 2

[0058] An oral spray for preventing and assisting the treatment of periodontitis, comprising the following percentages of raw materials:

[0059]

[0060] The sum of each component is 100%.

[0061] The above-mentioned preparation method of the oral spray for preventing and assisting the treatment of periodontitis comprises steps:

[0062] (1) Weighing 2g of epigallocatechin gallate, 0.5g of theaflavins, 0.5g of proanthocyanidin A1, 0.2g of xylitol, and 1g of citric acid were dissolved in 500g of sterile water, and mixed uniformly to obtain solution A;

[0063] (2) Weigh 0.5g licochalcone A, 0.5g rhododendron, 0.2g luteolin, 0.2g ferulic acid, 1g levomenthol, 0.5g notoginsenoside R1, 0.05g ginsenoside Rb1, 0.05 g emodin is configured into solution B with 20 g ethanol;

[0064] (3) Mix solution A and solution B evenly, add sterile water to 1000 g, filter and sterilize the obtained solution, and fill it in a spray bottle to obtain the product.

Embodiment 3

[0066] An oral spray for preventing and assisting the treatment of periodontitis, comprising the following percentages of raw materials:

[0067]

[0068] The sum of each component is 100%.

[0069] The above-mentioned preparation method of the oral spray for preventing and assisting the treatment of periodontitis comprises steps:

[0070] (1) Weighing 8g of epigallocatechin gallate, 3g of theaflavins, 3g of proanthocyanidin A1, 1g of xylitol, and 3g of citric acid were dissolved in 500g of sterile water, and mixed uniformly to obtain solution A;

[0071] (2) Weigh 3g licochalcone A, 3g rhododendron, 1g luteolin, 1g ferulic acid, 5g levomenthol, 3g notoginsenoside R1, 0.5g ginsenoside Rb1, 0.5g emodin with 80g Ethanol is configured into solution B;

[0072] (3) Mix solution A and solution B evenly, add sterile water to 1000 g, filter and sterilize the obtained solution, and fill it in a spray bottle to obtain the product.

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Abstract

The invention provides an oral spray for prevention and auxiliary treatment on periodontitis and a preparation method of the oral spray. The oral spray provided by the invention comprises the following raw materials: epigallocatechin gallate, theaflavin, procyanidine, licochalcone A, farrerol, luteolin, ferulic acid, menthol, notoginsenoside R1, xylitol, citric acid, rheum emodin, ginsenoside, ethanol and sterile water. The oral spray provided by the invention is free of toxic or side effect, has relatively good growth inhibition and sterilization function upon fusobacterium nucleatum, gingivaporphyrin monoucleosis, actinobacillus actinomycetemcomitans and the like in pathogenic bacteria of periodontitis, meanwhile is capable of inhibiting pathogenic bacterium polymerization and formationof biological membranes, has an antibacterial adhesion function, and meanwhile has the functions of inflammation elimination and alveolar resorption prevention.

Description

technical field [0001] The invention relates to an oral spray for preventing and assisting the treatment of periodontitis and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Periodontitis is a chronic infectious disease of periodontal support tissue caused by microorganisms in dental plaque, which can lead to the destruction of periodontal support tissue, and finally lead to alveolar bone resorption, tooth loosening and extraction. Pathogenic microorganisms in the oral cavity are the main cause of periodontitis. Inadequate attention to oral hygiene and bad oral habits in life will cause oral pathogenic bacteria to gather, multiply and cause periodontitis. If periodontitis is not treated in time, it will lead to serious alveolar bone resorption and serious loss of attachment, leading to the crisis of tooth loss, and may increase the risk of other oral diseases such as apical periodontitis or systemic diseases such as ...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61K31/352A61K31/12A61K31/192A61K31/045A61K31/704A61K31/047A61K31/194A61K31/122A61K9/12A61P1/02A61P31/04
CPCA61K9/006A61K31/045A61K31/047A61K31/12A61K31/122A61K31/192A61K31/194A61K31/352A61K31/353A61K31/704A61P1/02A61P31/04A61K2300/00
Inventor 冯强唐迪
Owner SHANDONG UNIV
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